Copper(II) Complexes of Salicylaldehyde Hydrazones: Synthesis, Structure, and DNA Interaction
| Autor: | Hanbing Teng, Lamei Wu, Wen-Jin Xu, Shucai Liang, Jiangtao Su, Xian-Ming Hu, Xianbing Ke |
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| Rok vydání: | 2007 |
| Předmět: |
Stereochemistry
Dna interaction Intercalation (chemistry) chemistry.chemical_element Bioengineering Crystal structure Crystallography X-Ray Biochemistry chemistry.chemical_compound Organometallic Compounds Molecule Molecular Biology Aldehydes Molecular Structure Hydrazones X-ray DNA General Chemistry General Medicine Copper Intercalating Agents Crystallography chemistry Salicylaldehyde Molecular Medicine |
| Zdroj: | Chemistry & Biodiversity. 4:2198-2209 |
| ISSN: | 1612-1880 1612-1872 |
| DOI: | 10.1002/cbdv.200790177 |
| Popis: | Three hydrazone ligands, H2L1-H2L3, made from salicylaldehyde and ibuprofen- or naproxen-derived hydrazides, were prepared and transformed into the corresponding copper(II) complexes [Cu(II)L1] x H2O, [Cu(II)L2], and [(Cu(II))2(L3)2] x H2O x DMF (Scheme). The X-ray crystal structure of the last-mentioned complex was solved (Fig. 1), showing a square-planar complexation geometry, and the single units were found to form a one-dimensional chain structure (Fig. 2). The interactions of these complexes with CT-DNA were studied by different techniques, indicating that they all bind to DNA by classical and/or non-classical intercalation modes. |
| Databáze: | OpenAIRE |
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