Sexual Function and Obstructive Sleep Apnea–Hypopnea: A Randomized Clinical Trial Evaluating the Effects of Oral-Appliance and Continuous Positive Airway Pressure Therapy

Autor: Johannes H. van der Hoeven, Aarnoud Hoekema, Mels F. van Driel, Lambert G.M. de Bont, Peter J. Wijkstra, Boudewijn Stegenga, Anna-Lucia Stel
Přispěvatelé: Faculteit Medische Wetenschappen/UMCG, Personalized Healthcare Technology (PHT), Groningen Research Institute for Asthma and COPD (GRIAC)
Rok vydání: 2007
Předmět:
Adult
Male
medicine.medical_specialty
DISORDERS
Polysomnography
Urology
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Oral appliance
design
male erectile disorder
SERUM
DESATURATION
Endocrinology
Erectile Dysfunction
TESTOSTERONE
Surveys and Questionnaires
Internal medicine
medicine
Humans
Continuous positive airway pressure
SATISFACTION GRISS
Sleep Apnea
Obstructive
Continuous Positive Airway Pressure
psychological assessment of sexual dysfunction
business.industry
Coitus
MEN
Middle Aged
medicine.disease
PREVALENCE
Obstructive sleep apnea
Psychiatry and Mental health
Male Erectile Disorder
Treatment Outcome
Sexual dysfunction
Erectile dysfunction
Reproductive Medicine
Patient Satisfaction
Research Design
methodology of clinical trials
GOLOMBOK-RUST INVENTORY
DUTCH POPULATION
Physical therapy
ERECTILE-DYSFUNCTION
medicine.symptom
Sexual function
business
Hypopnea
Zdroj: Journal of Sexual Medicine, 4(4), 1153-1162. ELSEVIER SCI LTD
ISSN: 1743-6095
DOI: 10.1111/j.1743-6109.2006.00341.x
Popis: Introduction The obstructive sleep apnea–hypopnea syndrome (OSAHS) is associated with sexual dysfunction. Although successful treatment with continuous positive airway pressure (CPAP) has been demonstrated to improve sexual function, the effects of oral-appliance therapy are unknown. Aim The aims of this study were to determine to what extent untreated male OSAHS patients experience sexual dysfunctions compared with control subjects, and second, to evaluate the effects of oral-appliance and CPAP therapy on sexual functioning. Methods Sexual functioning was determined in 48 OSAHS patients with the Golombok Rust inventory of sexual satisfaction (GRISS) and a testosterone measurement. GRISS outcomes were compared with 48 age-matched male controls without any sexual problems. Patients were randomized for either oral-appliance or CPAP therapy. After 2–3 months of treatment, the GRISS and testosterone measurements were repeated. Main Outcome Measure The outcomes on the GRISS were used as the main outcome measure. Results Compared with controls, OSAHS patients had significantly more erectile dysfunction (mean ± standard deviation; OSAHS 8.7 ± 3.8 vs. controls 6.8 ± 2.6) and sexual dissatisfaction (mean ± standard deviation; OSAHS 9.7 ± 4.2 vs. controls 8.1 ± 2.6) as indicated by the GRISS. No significant changes in the GRISS or testosterone levels were observed in the 20 and 27 patients completing the follow-up review for oral-appliance and CPAP therapy. A correlation was demonstrated between the extent of erectile dysfunction at baseline and improvements in erectile function following treatment ( r = −0.547, P = 0.000). Conclusions This study confirms that male OSAHS patients show more sexual dysfunctions compared with age-matched control subjects. Although significant improvements in sexual functioning in neither the oral-appliance nor CPAP-treated group could be established, our findings suggest that untreated OSAHS patients with pronounced erectile dysfunction experience some improvement following treatment. Hoekema A, Stel A-L, Stegenga B, van der Hoeven JH, Wijkstra PJ, van Driel MF, and de Bont LGM. Sexual function and obstructive sleep apnea–hypopnea: A randomized clinical trial evaluating the effects of oral-appliance and continuous positive airway pressure therapy.
Databáze: OpenAIRE
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