Weight-related differences in glucose metabolism and free fatty acid production in two South African population groups
| Autor: | Nigel J. Crowther, Glen Schlaphoff, M. Toman, M-T van der Merwe, I. P. Gray, Chamindie Punyadeera, A. R. Immelman |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Leptin medicine.medical_specialty Endocrinology Diabetes and Metabolism Black People Medicine (miscellaneous) Fatty Acids Nonesterified White People South Africa Insulin resistance Internal medicine Diabetes mellitus medicine Humans Obesity Carbon Isotopes Glucose tolerance test Nutrition and Dietetics medicine.diagnostic_test Tumor Necrosis Factor-alpha business.industry Body Weight Area under the curve Fasting Glucose Tolerance Test medicine.disease Black or African American Glucose Postprandial Endocrinology Adipose Tissue Breath Tests Area Under Curve Body Composition Female business Bioelectrical impedance analysis |
| Zdroj: | International Journal of Obesity. 25:1196-1205 |
| ISSN: | 1476-5497 0307-0565 |
| DOI: | 10.1038/sj.ijo.0801660 |
| Popis: | OBJECTIVE: The effects of free fatty acids (FFA), leptin, tumour necrosis factor (TNF) α and body fat distribution on in vivo oxidation of a glucose load were studied in two South African ethnic groups. DESIGN AND MEASUREMENTS: Anthropometric and various metabolic indices were measured at fasting and during a 7 h oral glucose tolerance test (OGTT). Body composition was measured using bioelectrical impedance analysis and subcutaneous and visceral fat mass was assessed using a five- and two-level CT-scan respectively. Glucose oxidation was evaluated by measuring the ratio of 13CO2 to 12CO2 in breath following ingestion of 1-13C-labelled glucose. SUBJECTS: Ten lean black women (LBW), ten obese black women (OBW), nine lean white women (LWW) and nine obese white women (OWW) were investigated after an overnight fast. RESULTS: Visceral fat levels were significantly higher (P |
| Databáze: | OpenAIRE |
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