Krill Oil Attenuates Cognitive Impairment by the Regulation of Oxidative Stress and Neuronal Apoptosis in an Amyloid β-Induced Alzheimer’s Disease Mouse Model

Autor: Eun Ju Cho, Ji Myung Choi, Mei Tong He, Dongjun Lee, Ji Hyun Kim, Hui Wen Meng
Jazyk: angličtina
Rok vydání: 2020
Předmět:
cognition
Pharmaceutical Science
Morris water navigation task
Apoptosis
medicine.disease_cause
Analytical Chemistry
memory
chemistry.chemical_compound
Mice
0302 clinical medicine
Drug Discovery
oxidative stress
chemistry.chemical_classification
Neurons
0303 health sciences
biology
Behavior
Animal
krill oil
Malondialdehyde
Chemistry (miscellaneous)
Fatty Acids
Unsaturated
Molecular Medicine
Alzheimer’s disease
medicine.medical_specialty
Amyloid beta
Oxidative phosphorylation
Krill oil
Article
Nitric oxide
lcsh:QD241-441
03 medical and health sciences
lcsh:Organic chemistry
Alzheimer Disease
Internal medicine
medicine
Animals
Cognitive Dysfunction
Physical and Theoretical Chemistry
Maze Learning
030304 developmental biology
Reactive oxygen species
Amyloid beta-Peptides
business.industry
Organic Chemistry
amyloid beta
Disease Models
Animal
Endocrinology
chemistry
biology.protein
business
Reactive Oxygen Species
030217 neurology & neurosurgery
Oxidative stress
Biomarkers
Euphausiacea
Zdroj: Molecules
Volume 25
Issue 17
Molecules, Vol 25, Iss 3942, p 3942 (2020)
ISSN: 1420-3049
DOI: 10.3390/molecules25173942
Popis: In the present study, we investigated the cognitive improvement effects and its mechanisms of krill oil (KO) in A&beta
25&ndash
35-induced Alzheimer&rsquo
s disease (AD) mouse model. The A&beta
35-injected AD mouse showed memory and cognitive impairment in the behavior tests. However, the administration of KO improved novel object recognition ability and passive avoidance ability compared with A&beta
35-injected control mice in behavior tests. In addition, KO-administered mice showed shorter latency to find the hidden platform in a Morris water maze test, indicating that KO improved learning and memory abilities. To evaluate the cognitive improvement mechanisms of KO, we measured the oxidative stress-related biomarkers and apoptosis-related protein expressions in the brain. The administration of KO inhibited oxidative stress-related biomarkers such as reactive oxygen species, malondialdehyde, and nitric oxide compared with AD control mice induced by A&beta
35. In addition, KO-administered mice showed down-regulation of Bax/Bcl-2 ratio in the brain. Therefore, this study indicated that KO-administered mice improved cognitive function against A&beta
35 by attenuations of neuronal oxidative stress and neuronal apoptosis. It suggests that KO might be a potential agent for prevention and treatment of AD.
Databáze: OpenAIRE
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