An alternative two stage method via the EM-algorithm for the estimation of population pharmacokinetic parameters

Autor:	Takashi Amisaki, Tohoru Tatsuhara
Rok vydání:	1988
Předmět:	Pharmacology Estimation Accuracy and precision education.field_of_study Population NONMEM Microcomputers Pharmacokinetics Convergence (routing) Statistics Expectation–maximization algorithm Humans Computer Simulation Stage (hydrology) education Algorithms Probability Mathematics
Zdroj:	Journal of Pharmacobio-Dynamics. 11:335-348
ISSN:	1881-1353 0386-846X
DOI:	10.1248/bpb1978.11.335
Popis:	There has been a considerable increase in popularity of the NONMEM method as a technique for estimating population pharmacokinetic parameters. The authors present another approach to population pharmacokinetic analysis, the alternative two stage method (ATS). ATS uses the EM-algorithm for maximizing the likelihood of variance components. The performance of ATS was compared with the NONMEM method on a microcomputer. Simulation studies showed that the precision and accuracy of estimates obtained with ATS were comparable to the NONMEM method, however, the computation time, dependences on initial estimates and convergence properties were somewhat different. ATS could be a valuable alternative to the NONMEM method for estimating population pharmacokinetic parameters in some cases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0bdb199d14122768d9caa31d3d8ff2 https://doi.org/10.1248/bpb1978.11.335 Zobrazit plný text záznamu