Circulating CD133+/ESA+ cells in colorectal cancer patients
| Autor: | Shung Haur Yang, Jeng Kai Jiang, Chih Yung Yang, Chi Hung Lin, Ju Yu Tseng, Jeng Kou Lin |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Pathology Colorectal cancer Taiwan Gastroenterology Disease-Free Survival Tumor Initiating Cells Flow cytometry chemistry.chemical_compound Antigen Antigens CD Antigens Neoplasm hemic and lymphatic diseases Internal medicine medicine Humans AC133 Antigen Prospective Studies Stage (cooking) neoplasms Aged Glycoproteins Proportional Hazards Models medicine.diagnostic_test business.industry Epithelial cell adhesion molecule Venous blood Epithelial Cell Adhesion Molecule medicine.disease chemistry Cancer cell Neoplastic Stem Cells Female Surgery Colorectal Neoplasms Peptides business Cell Adhesion Molecules |
| Zdroj: | Journal of Surgical Research. 199:362-370 |
| ISSN: | 0022-4804 |
| Popis: | Background Tumor initiating cells are a small subset of cancer cells responsible for tumor growth and recurrence. The status of tumor initiating cells was measured using the surface markers CD133 (prominin-1) and ESA (epithelial-specific antigen). The aims of this study were to investigate the significance of CD133+/ESA+ cells in mesenteric venous blood (MVB) and tumor mass (TM) for overall survival (OS) and disease-free survival (DFS) in colorectal cancer (CRC) patients undergoing curative resection. Materials and methods A total of 229 CRC patients undergoing curative resection were prospectively enrolled in the study. Using CD133 and ESA as surface markers, CD133+/ESA+ cells were enumerated from MVB and TM using flow cytometry. Results We analyzed the presence of CD133+/ESA+ cells in TM from 158 patients and found no correlation to patient DFS, OS, or clinical stage. In 135 patients, an analysis of CD133+/ESA+ cells in MVB showed an inverse correlation with both DFS and OS (P = 0.014 and P = 0.008, respectively). It exhibited an increase-then-decrease pattern with the peak in stage II patients. A multivariate Cox analysis demonstrated that the status of CD133+/ESA+ cells in MVB, but not the TM, was a significant prognostic factor for DFS and OS (P = 0.003 and P = 0.011, respectively). Conclusions The status of CD133+/ESA+ cells in MVB, but not in TM, could be a useful indicator for predicting tumor recurrence and a prognostic marker for CRC patients. |
| Databáze: | OpenAIRE |
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