The neural correlates of low social integration as a risk factor for suicide
| Autor: | Ricardo Cáceda, G. Andrew James, Clint D. Kilts, Pedro L. Delgado, Nolan C. Kordsmeier, Zachary N. Stowe |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Adolescent Suicide Attempted Gyrus Cinguli Severity of Illness Index Social Inclusion Article Suicidal Ideation 03 medical and health sciences Young Adult 0302 clinical medicine Social integration Risk Factors Connectome Medicine Humans Pharmacology (medical) Suicidal ideation Biological Psychiatry Anterior cingulate cortex Depression (differential diagnoses) Cerebral Cortex Brain Mapping Depressive Disorder Suicide attempt medicine.diagnostic_test business.industry General Medicine Middle Aged Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Social Isolation Psychological pain Female medicine.symptom business Functional magnetic resonance imaging Insula 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Eur Arch Psychiatry Clin Neurosci |
| Popis: | Low social integration is commonly described in acutely suicidal individuals. Neural mechanisms underlying low social integration are poorly understood in depressed and suicidal patients. We sought to characterize the neural response to low social integration in acutely suicidal patients. Adult depressed patients within 3 days of a suicide attempt (n = 10), depressed patients with suicidal ideation (n = 9), non-suicidal depressed patients (n = 15), and healthy controls (N = 18) were administered the Cyberball Game while undergoing functional magnetic resonance imaging. We used complementary functional connectivity and region of interest data analysis approaches. There were no group differences in functional connectivity within neural network involving the pain matrix, nor in insula neural activity or the insula during either social inclusion. Superior anterior insula activity exhibited an inverted U-shaped curve across the suicide risk spectrum during social inclusion. Superior insula activity during social inclusion correlated with depression severity and psychological pain. Dorsal anterior cingulate cortex activity during social exclusion correlated with physical pain severity. Neural responses in the anterior insula significantly correlated with depression severity and with psychological pain during social inclusion, whereas dACC activity significantly correlated with physical pain during social exclusion. Recent suicidal behavior seems associated with a distinct neural response to social exclusion independently of presence of depression or suicidal thoughts. |
| Databáze: | OpenAIRE |
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