Clozapine Administration Modifies Neurotensin Effect on Synaptosomal Membrane Na+, K+ -ATPase Activity
| Autor: | María Graciela López Ordieres, Georgina Rodríguez de Lores Arnaiz |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Dopamine Sodium-Potassium-Exchanging ATPase Synaptic Membranes Pharmacology Biochemistry Cellular and Molecular Neuroscience chemistry.chemical_compound Dopamine receptor D2 Internal medicine medicine Animals Rats Wistar Na+/K+-ATPase Receptor Clozapine Neurotensin Cerebral Cortex Receptors Dopamine D2 Dopaminergic General Medicine Rats Endocrinology chemistry Synaptosomes medicine.drug |
| Zdroj: | Neurochemical Research. 34:2226-2232 |
| ISSN: | 1573-6903 0364-3190 |
| DOI: | 10.1007/s11064-009-0018-5 |
| Popis: | Na+, K+-ATPase is inhibited by neurotensin, an effect which involves the peptide high affinity receptor (NTS1). Neurotensin effect on cerebral cortex synaptosomal membrane Na+, K+-ATPase activity of rats injected i.p. with antipsychotic clozapine was studied. Whereas 3.5 x 10(-6) M neurotensin decreased 44% Na+, K+-ATPase activity in the controls, the peptide failed to modify enzyme activity 30 min after a single 3.0, 10.0 and 30.0 mg/kg clozapine dose. Neurotensin decreased Na+, K+-ATPase activity 40 or 20% 18 h after 3.0 or 5.6 mg/kg clozapine administration, respectively, and lacked inhibitory effect 18 h after 17.8 and 30.0 mg/kg clozapine doses. Results indicated that the clozapine treatment differentially modifies the further effect of neurotensin on synaptosomal membrane Na+, K+-ATPase activity according to time and dose conditions employed. Taken into account that clozapine blocks the dopaminergic D2 receptor, findings obtained favor the view of an interplay among neurotensinergic receptor, dopaminergic D2 receptor and Na+, K+-ATPase at synaptic membranes. |
| Databáze: | OpenAIRE |
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