Altered expression of NFY-C and RORA in colorectal adenocarcinomas
| Autor: | Theodore Petsas, Athanasios Tsamandas, Haralabos P. Kalofonos, Anna G. Antonacopoulou, Anastasia E. Kottorou, Chrisoula D. Scopa, Fotinos-Ioannis D. Dimitrakopoulos |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Histology Steroid hormone receptor Cell Adenocarcinoma Biology Real-Time Polymerase Chain Reaction Internal medicine medicine Humans RNA Messenger Transcription factor Aged Neoplasm Staging Regulation of gene expression Gene Expression Profiling Nuclear Receptor Subfamily 1 Group F Member 1 Promoter Cell Biology General Medicine Immunohistochemistry digestive system diseases Gene Expression Regulation Neoplastic Gene expression profiling Real-time polymerase chain reaction medicine.anatomical_structure Endocrinology CCAAT-Binding Factor Disease Progression Cancer research Female Colorectal Neoplasms |
| Zdroj: | Acta Histochemica. 114:553-561 |
| ISSN: | 0065-1281 |
| Popis: | NFY-C, a subunit of the transcription factor NFY, binds to the promoters of several eukaryotic genes, including cell cycle-related genes. RORA is a steroid hormone receptor implicated in a range of important cellular processes. We evaluated the expression of NFY-C and RORA in colorectal adenocarcinomas and normal colonic tissue. NFY-C expression was elevated in adenocarcinomas. Moreover, NFY-C mRNA levels correlated with time to disease progression, while NFY-C protein expression was significantly higher in metastatic disease. RORA expression was downregulated in CRC adenocarcinomas compared to normal controls and correlated with time to disease progression. The role of NFY-C and RORA in CRC merits further investigation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect