Systematic review and consensus definitions for standardised endpoints in perioperative medicine : postoperative cancer outcomes
| Autor: | Monty G. Mythen, Ronald B. George, Hilary P. Grocott, Christopher L. Wu, Andy Klein, Keyvan Karkouti, M. Gabreu, Justyna Bartoszko, Tony Gin, David Mazer, Bilal Alkhaffaf, A. Kurz, Oliver Boney, Cornelis J. Kalkman, David R. McIlroy, P. Peyton, S. Dieleman, N. Stevenson, Mark D. Neuman, Stephen Morris, Rupert M Pearse, Ramani Moonesinghe, Matthew T. V. Chan, Lisbeth Evered, Donal J. Buggy, Guy Haller, R. Eckenhoff, MJ Schultz, Timothy G. Short, E. Diouf, Lars S. Rasmussen, D. Jamie Cooper, Tom E.F. Abbott, Emmanuel Futier, Nathan L. Pace, Andre Lamy, Scott Beattie, D. I. Sessler, Lars Eriksson, P. Myles, Jaume Canet, Paolo Pelosi, M. Jayarajah, David Scott, A. Cyna, Simon J. Howell, S. Jackson, Mark Johnson, Bruce M Biccard, Ben Creagh-Brown, Ann Merete Møller, Rinaldo Bellomo, Ulrica Nilsson, Toby Richards, Bernhard Riedel, Peter Nagele, W. A. van Klei, Timothy E. Miller, Mark A Shulman, Kate Leslie, G. S. De Oliveira, Mari Botti, Tim Cook, J. Billings, Tong J. Gan, Tomas Corcoran, Brendan S. Silbert, Michael P.W. Grocott, Duminda N. Wijeysundera, David A Story, Sohail Bampoe, Meghan B. Lane-Fall, M.-B. Jensen, R. Sneyd, Manoj M. Lalu, Russell L. Gruen, James Freeman, John R. Prowle, D. van Dijk, Martin R. Tramèr, Luca Cabrini, Michael P. Murphy, Giovanni Landoni, Henrik Kehlet, Lee A. Fleisher, Andrew D. Shaw, Vijaya Gottumukkala |
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| Přispěvatelé: | Buggy, Dj, Freeman, J, Johnson, Mz, Leslie, K, Riedel, B, Sessler, Di, Kurz, A, Gottumukkala, V, Short, T, Pace, N, Myles, P, StEP-COMPAC, Group, Landoni, G, Intensive Care Medicine, ACS - Diabetes & metabolism, ACS - Pulmonary hypertension & thrombosis, ACS - Microcirculation, Haller, Guy Serge Antoine, Tramer, Martin |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
postoperative outcomes
Delphi method surgery 0302 clinical medicine Neoplasms / surgery 030202 anesthesiology Neoplasms cancer recurrence cancer surgery clinical trials endpoints surgery postoperative outcomes Consensus Disease-Free Survival Endpoint Determination Humans Perioperative Care Postoperative Care Survival Analysis Treatment Outcome Anesthesiology and Pain Medicine Medicine Postoperative Care / standards Perioperative medicine Manchester Cancer Research Centre ddc:617 surgery postoperative outcome Neoplasms/surgery 030220 oncology & carcinogenesis clinical trials endpoint Endpoint Determination / standards medicine.medical_specialty recurrence endpoints Perioperative Care/standards 03 medical and health sciences Anesthesiology Endpoint Determination/standards cancer Intensive care medicine Survival analysis clinical trials Clinical trials endpoints business.industry ResearchInstitutes_Networks_Beacons/mcrc Surgery postoperative outcomes Cancer Perioperative Care / standards medicine.disease Clinical trial Clinical research Systematic Review Postoperative Care/standards business Cancer surgery |
| Zdroj: | British Journal of Anaesthesia, 121(1), 38. Oxford University Press British journal of anaesthesia, 121(1), 38-44. Oxford University Press British journal of anaesthesia, Vol. 121, No 1 (2018) pp. 38-44 The StEP-COMPAC Group 2018, ' Systematic review and consensus definitions for standardised endpoints in perioperative medicine : postoperative cancer outcomes ', British Journal of Anaesthesia, vol. 121, no. 1, pp. 38-44 . https://doi.org/10.1016/j.bja.2018.03.020 |
| ISSN: | 0007-0912 |
| DOI: | 10.1016/j.bja.2018.03.020 |
| Popis: | Background: The Standardising Endpoints for Perioperative Medicine group was established to derive an appropriate set of endpoints for use in clinical trials related to anaesthesia and perioperative medicine. Anaesthetic or analgesic technique during cancer surgery with curative intent may influence the risk of recurrence or metastasis. However, given the current equipoise in the existing literature, prospective, randomised, controlled trials are necessary to test this hypothesis. As such, a cancer subgroup was formed to derive endpoints related to research in onco-anaesthesia based on a current evidence base, international consensus and expert guidance.Methods: We undertook a systematic review to identify measures of oncological outcome used in the oncological, surgical, and wider literature. A multiround Delphi consensus process that included up to 89 clinician–researchers was then used to refine a recommended list of endpoints.Results: We identified 90 studies in a literature search, which were the basis for a preliminary list of nine outcome measures and their definitions. A further two were added during the Delphi process. Response rates for Delphi rounds one, two, and three were 88% (n=9), 82% (n=73), and 100% (n=10), respectively. A final list of 10 defined endpoints was refined and developed, of which six secured approval by ≥70% of the group: cancer health related quality of life, days alive and out of hospital at 90 days, time to tumour progression, disease-free survival, cancer-specific survival, and overall survival (and 5-yr overall survival).Conclusion: Standardised endpoints in clinical outcomes studies will support benchmarking and pooling (meta-analysis) of trials. It is therefore recommended that one or more of these consensus-derived endpoints should be considered for inclusion in clinical trials evaluating a causal effect of anaesthesia–analgesia technique on oncological outcomes. |
| Databáze: | OpenAIRE |
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