Anastomotic stenting in a porcine aortoiliac graft model
| Autor: | D. Lootz, Karlheinz Hauenstein, L. Ketner, Sven Kramer, Wolfgang Schareck, K. Sternberg, C.M. Bünger, Ernst Klar, K.-H. Schmitz, Chr. Kröger, Hans Jürgen Kreutzer, N. Grabow |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Swine medicine.medical_treatment Computed tomography Constriction Pathologic Anastomosis Iliac Artery chemistry.chemical_compound Medicine Animals cardiovascular diseases Aorta Polytetrafluoroethylene General Veterinary medicine.diagnostic_test business.industry Anastomosis Surgical Lower edge Stent equipment and supplies medicine.disease Balloon dilatation catheter Surgery Abdominal incision Stenosis surgical procedures operative chemistry Models Animal Animal Science and Zoology Female Stents business Tomography X-Ray Computed |
| Zdroj: | Laboratory animals. 41(1) |
| ISSN: | 0023-6772 |
| Popis: | The purpose of the study was to evaluate the feasibility of anastomotic stent application in a porcine aortoiliac graft model. In a total of 10 pigs, a polytetrafluoroethylene aortobi-iliac graft was implanted through a midline abdominal incision. The lower edge of the iliac vessel was graft-inverted about 1 mm to produce irregularities at the downstream anastomosis. After transverse graft incision, six stainless-steel stents, six poly-L-lactic acid (PLLA) stents and four PLLA stents with 10% polycaprolactone (PCL) were implanted at the iliac anastomotic site using a 6 mm balloon dilatation catheter. Four anastomotic sites were left untreated. After two weeks, the patency of graft limbs was evaluated by contrast-enhanced computed tomography (CT). Both metal and polymeric stent designs provided adequate flexibility to manoeuvre across the anastomotic site for expansion in the chosen position. After deployment, the stent–arterial wall contact was complete on a macroscopic view. On CT scan, all metal and PLLA-stented graft limbs were free of stenosis, whereas all PLLA/PCL stents were occluded. The non-stented graft limbs showed a stenosis of 50–70%. In summary, this model is feasible to assess preclinically the deployment and patency rate of an anastomotic stent and to test future stent developments. |
| Databáze: | OpenAIRE |
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