Prevention of gram-positive sepsis in neonates weighing less than 1500 grams
| Autor: | Roberta Sandler, Richard A. Venezia, Michael J. Horgan, Luis Ochoa, Martha L. Lepow, Marilyn A. Kacica |
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| Rok vydání: | 1994 |
| Předmět: |
Coagulase
Pediatrics medicine.medical_specialty Neonatal intensive care unit medicine.drug_class Birth weight Antibiotics Population Bacteremia Gram-Positive Bacteria Vancomycin medicine Humans Prospective Studies education education.field_of_study business.industry Infant Newborn Infant Low Birth Weight Staphylococcal Infections medicine.disease Surgery Low birth weight Parenteral nutrition Pediatrics Perinatology and Child Health Parenteral Nutrition Total medicine.symptom business medicine.drug |
| Zdroj: | The Journal of pediatrics. 125(2) |
| ISSN: | 0022-3476 |
| Popis: | A prospective, randomized study to evaluate the effectiveness of a continuous low-dose vancomycin infusion to prevent nosocomial gram-positive bacteremia was initiated within the first 2 weeks of life in neonates weighing < 1500 gm. Seventy-one infants received constant infusion of vancomycin (25 micrograms/ml) mixed with their total parenteral nutrition solution; 70 infants served as control subjects. The groups were clinically similar in birth weight, estimated gestational age, and severity of illness. Administration of vancomycin was begun at a mean age of 5.4 +/- 2.9 days. Infants had mean serum vancomycin concentrations of 2.4 micrograms/ml, and received vancomycin for a mean of 11 +/- 7 days. No vancomycin-resistant organisms were detected in surveillance cultures during the 2-year study period. Twenty-four of seventy control infants, in comparison with 1 of 71 infants receiving vancomycin, had gram-positive bacteremia (p < 0.001). The addition of a low dose of vancomycin to alimentation fluids virtually eliminated the incidence of gram-positive bacteremia in an at-risk population of very low birth weight infants. However, the widespread use of vancomycin in total parenteral nutrition solution is not recommended until better data on the emergence of vancomycin-resistant organisms are available. |
| Databáze: | OpenAIRE |
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