Modeling of 24-Hour Glucose and Insulin Profiles of Patients With Type 2 Diabetes
| Autor: | Mats O. Karlsson, Nicolas Frey, Petra M. Jauslin |
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| Rok vydání: | 2011 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty medicine.medical_treatment Context (language use) Type 2 diabetes Models Biological Internal medicine Diabetes mellitus medicine Homeostasis Humans Insulin Glucose homeostasis Pharmacology (medical) Circadian rhythm Pharmacology Glucose tolerance test medicine.diagnostic_test business.industry Glucose Tolerance Test Middle Aged medicine.disease Circadian Rhythm Endocrinology Diabetes Mellitus Type 2 Nonlinear Dynamics Female business |
| Zdroj: | The Journal of Clinical Pharmacology. 51:153-164 |
| ISSN: | 0091-2700 |
| DOI: | 10.1177/0091270010362536 |
| Popis: | A model able to simultaneously characterize and simulate 24-hour glucose and insulin profiles following multiple meal tests was developed, extending an integrated glucose-insulin model for oral glucose tolerance tests that was previously published. The analysis was based on glucose and insulin measurements from 59 placebo-treated patients with type 2 diabetes. Circadian variations in glucose homeostasis were assessed on relevant parameters based on literature review. They were best described by a nighttime dip in insulin secretion between approximately 9 p.m. and 5 a.m. using a modulator function. The integrated glucose-insulin model has thus been shown to be applicable to real-life situations determined by multiple meals over the course of a day. This provides the basis for the analysis and simulation of long-term glucose and insulin data. The model may also prove useful for understanding antidiabetic drug actions and requirements in the context of circadian changes in glucose-insulin regulation. |
| Databáze: | OpenAIRE |
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