Effect of fatty fish or nut consumption on concentrations of persistent organic pollutants in overweight or obese men and women: A randomized controlled clinical trial
| Autor: | Hanne L. Gulseth, Tor Ole Klemsdal, Sasa Dusanov, Hannu Kiviranta, Mette Svendsen, Jérôme Ruzzin, Serena Tonstad |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pollutant
Animal fat Nutrition and Dietetics business.industry Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Adipose tissue Physiology 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Overweight medicine.disease Obesity Clinical trial 03 medical and health sciences 0302 clinical medicine medicine medicine.symptom Metabolic syndrome Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | NMCD. Nutrition Metabolism and Cardiovascular Diseases |
| Popis: | Background and aims While excess energy intake and physical inactivity constitute the obvious causes of body fat accumulation, persistent organic pollutants (POPs) are novel factors that have been linked to cardiometabolic disorders. Major sources of POPs are animal fats including fatty fish. Given the putative protective effects of fish on cardiovascular disease, we explored whether high consumption of fatty fish increased serum concentrations of POPs. Methods and results Men and women aged 35–70 years with body mass index between 25 and 38 kg/m2 and at least 1 cardiometabolic component were randomized to high intakes of fatty fish (mostly farmed salmon, ∼630 g/week; n = 45), high intakes of nuts (∼200 g/week; n = 42) or a control group following their usual diet but restricting fatty fish and nuts for 6 months (n = 44). Concentrations of 15 POPs (5 organochlorinated compounds, 2 dioxin-like polychlorinated biphenyls and 8 non-dioxin-like polychlorinated biphenyls) and cardiometabolic risk factors were measured at baseline and end of the study. Results showed that changes in concentrations of individual and classes of POPs did not differ between the dietary groups and controls (p > 0.05). Among cardiometabolic risk factors HDL-cholesterol increased in the fatty fish group compared to controls (+0.10 mmol/L, CI (0.05–0.20); p = 0.005) while no changes were observed in the group consuming nuts. Conclusion Fatty fish consumption for 6 months did not increase the serum concentrations of POPs in individuals with overweight or obesity and metabolic risk. While this finding appears reassuring regarding short-term intakes of farmed salmon, long term variations in POPs in adipose stores require further study. |
| Databáze: | OpenAIRE |
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