Ulinastatin improved cardiac dysfunction after cardiac arrest in New Zealand rabbits
| Autor: | Chun Lin Hu, Xiaoyun Zeng, Jin Ming Xia, Gang Dai, Xiao Xing Liao, Xin Li, Hui Li, Xiao Li Jing, Hong Zhan |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Cardiac function curve medicine.drug_class medicine.medical_treatment Kaplan-Meier Estimate Return of spontaneous circulation Protective Agents Ventricular Function Left Random Allocation chemistry.chemical_compound Troponin I medicine Natriuretic peptide Animals cardiovascular diseases Cardiopulmonary resuscitation Glycoproteins Ultrasonography Ejection fraction business.industry Stroke Volume General Medicine Ulinastatin medicine.disease Cardiopulmonary Resuscitation Heart Arrest Treatment Outcome chemistry Anesthesia Ventricular fibrillation Emergency Medicine Rabbits Blood Gas Analysis Trypsin Inhibitors business Biomarkers |
| Zdroj: | The American Journal of Emergency Medicine. 31:768-774 |
| ISSN: | 0735-6757 |
| DOI: | 10.1016/j.ajem.2012.11.012 |
| Popis: | The present study was designed to evaluate the effects of ulinastatin (UTI) on cardiac dysfunction after cardiopulmonary resuscitation (CPR).A total of 48 healthy adult male New Zealand rabbits were untreated for 8 minutes after the induction of ventricular fibrillation (VF) by an external transthoracic alternating current and then treated by CPR. These rabbits were then randomly divided into the control and UTI groups after the return of spontaneous circulation (ROSC) and were observed for 8 hours after the ROSC. Before CPR and after ROSC at 2, 4, and 8 hours, blood samples were collected to determine the levels of tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), malondialdehyde (MDA), cardiac troponin I (cTnI), and N-terminal probrain natriuretic peptide (NT-proBNP), and the left ventricular ejection fraction (EF) was measured by echocardiography.Nineteen of 24 rabbits in the control group and 18 of 24 in the UTI group were successfully resuscitated. The plasma levels of TNF-α, IL-6, MDA, cTnI, and NT-proBNP were significantly increased, accompanying a deceased EF in the control group, but the cotreatment with UTI decreased the plasma levels of TNF-α, IL-6, MDA, cTnI, and NT-proBNP (P.05), attenuating the myocardial injury and improving the EF in the UTI group. Only 9 of 19 animals in the control group but 14 of 18 animals in the UTI group survived longer than 8 hours (P = .011).The progression of proinflammatory responses, oxidative stress, and myocardial injury have been linked to the reduced EF after VF/CPR, and the administration of UTI at a cardioprotective dosage preserved the cardiac function after VF/CPR. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect