Nephrocalcinosis in Sjögren's syndrome: a late sequela of renal tubular acidosis
| Autor: | F. N. Skopouli, J. Cledes, Haralampos M. Moutsopoulos, P. Youinou, M. S. Elisaf |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
medicine.medical_specialty Pathology Interstitial nephritis Anion gap urologic and male genital diseases Gastroenterology Hypergammaglobulinemia/complications Renal tubular acidosis Kidney Calculi Distal renal tubular acidosis Hypergammaglobulinemia Internal medicine Internal Medicine medicine Humans Hypercalciuria Acidosis business.industry Metabolic acidosis Acidosis Renal Tubular/*complications/physiopathology Acidosis Renal Tubular Middle Aged medicine.disease Kidney Calculi/etiology Nephrocalcinosis Sjogren's Syndrome Sjogren's Syndrome/*complications/physiopathology Nephrocalcinosis/complications/*etiology Female medicine.symptom business |
| Zdroj: | Journal of Internal Medicine. 230:187-191 |
| ISSN: | 1365-2796 0954-6820 |
| Popis: | Sjogren's syndrome (SS) is an autoimmune exocrinopathy that develops into systemic autoimmune disease in 25% of patients, leading to general complications, one of which is kidney involvement. It presents mainly as interstitial nephritis, disclosed by hyposthenuria, distal renal tubular acidosis (RTA) and diabetes insipidus. We here describe five cases of SS with type-1 RTA (hyperchloraemic metabolic acidosis with an anion gap and alkaline urine pH) who developed nephrolithiasis, nephrocalcinosis and renal insufficiency. Hypercalciuria due to acidosis was the main nephrocalcinosis-prone factor in four patients; four subjects displayed diminished renal concentrating capacity, and two had hypokalaemia. J Intern Med |
| Databáze: | OpenAIRE |
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