Somatostatin receptor scintigraphy in the differential diagnosis of meningioma
| Autor: | Malte Clausen, N. Jahn, A. Behnke, Eberhard Henze, H.-H. Hugo, Winfried Brenner, H. Wolf, K. H. Bohuslavizki, C. Sippel, H. M. Mehdorn, W. E. K. Braunsdorf, S. Tinnemeyer |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Ependymoma Octreotide Scintigraphy Diagnosis Differential Meningioma parasitic diseases Meningeal Neoplasms otorhinolaryngologic diseases medicine Humans Radiology Nuclear Medicine and imaging Receptors Somatostatin Radionuclide Imaging False Negative Reactions neoplasms Aged Aged 80 and over medicine.diagnostic_test business.industry Histology Magnetic resonance imaging General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging nervous system diseases Functional imaging Somatostatin Female Differential diagnosis business Nuclear medicine Neurilemmoma |
| Zdroj: | Nuclear Medicine Communications. 17:302-310 |
| ISSN: | 0143-3636 |
| Popis: | The aim of this study was to evaluate somatostatin receptor scintigraphy (SRS) in patients with meningioma proven or suspected on magnetic resonance imaging (MRI). Prior to surgery, 47 patients were investigated up to 24 h following the injection of 200 MBq 111 In-octreotide. Tracer uptake was compared with the histological presence of meningioma. Histology revealed 43 meningiomas, 3 neurinomas and 1 ependymoma. A true-positive SRS result was obtained in 36 patients, in 13 of whom a tumour volume of < 10 ml was noted. A false-negative SRS result was obtained in seven patients, all of whom had a tumour volume of < 10 ml. Whereas MRI alone was decisive in 38 of 47 patients, it could only provide a differential diagnosis in the remaining 9 patients. A positive SRS result confirmed meningioma in five of these patients, and a negative SRS result excluded meningioma in the other four. Therefore, cases of SRS-negative meningioma do exist. Nevertheless, significant clinical benefit can be obtained from functional imaging with 111 In-octreotide in patients with an inconclusive MRI result, as large meningiomas can be excluded by scintigraphy alone, whereas meningiomas of any size may be confirmed in combination with specific MRI results. |
| Databáze: | OpenAIRE |
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