Fractional flow reserve versus angiography for guiding percutaneous coronary intervention
| Autor: | Tonino, Pim A L, De Bruyne, Bernard, Pijls, Nico H J, Siebert, Uwe, Ikeno, Fumiaki, van' t Veer, Marcel, Klauss, Volker, Manoharan, Ganesh, Engstrøm, Thomas, Oldroyd, Keith G, Ver Lee, Peter N, MacCarthy, Philip A, Fearon, William F, Rasmussen [FAME study investigators], Klaus, Frøbert [FAME study investigators], Ole |
|---|---|
| Přispěvatelé: | Cardiovascular Biomechanics, Tonino, Pim A. L, De Bruyne, Bernard, Pijls, Nico H. J, Siebert, Uwe, Ikeno, Fumiaki, van' t. Veer, Marcel, Klauss, Volker, Manoharan, Ganesh, Engstrøm, Thoma, Oldroyd, Keith G, Ver Lee, Peter N, Barbato, Emanuele, Maccarthy, Philip A, Fearon, William F. |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_treatment Aged Angioplasty Balloon Coronary Coronary Artery Disease Coronary Restenosis Female Follow-Up Studies Health Care Costs Humans Kaplan-Meier Estimate Length of Stay Middle Aged Myocardial Infarction Retreatment Stents Coronary Angiography Drug-Eluting Stents Fractional Flow Reserve Myocardial Fractional flow reserve Coronary artery disease Coronary Restenosi Stent Drug-Eluting Stent Angioplasty Transluminal Percutaneous Coronary Myocardial infarction Angioplasty Balloon Coronary medicine.diagnostic_test General Medicine Fractional Flow Reserve Myocardial surgical procedures operative Cardiology Radiology Human medicine.medical_specialty Follow-Up Studie Internal medicine medicine cardiovascular diseases Kaplan-Meiers Estimate business.industry Percutaneous coronary intervention medicine.disease Health Care Cost Angiography Conventional PCI business |
| Zdroj: | The New England Journal of Medicine, 360(3), 213-224. Massachussetts Medical Society Tonino, P A L, De Bruyne, B, Pijls, N H J, Siebert, U, Ikeno, F, van' t Veer, M, Klauss, V, Manoharan, G, Engstrøm, T, Oldroyd, K G, Ver Lee, P N, MacCarthy, P A, Fearon, W F, FAME Study Investigators, Rasmussen [FAME study investigators], K & Frøbert [FAME study investigators], O 2009, ' Fractional flow reserve versus angiography for guiding percutaneous coronary intervention ', The New England Journal of Medicine, vol. 360, no. 3, pp. 213-24 . https://doi.org/10.1056/NEJMoa0807611 |
| ISSN: | 0028-4793 |
| DOI: | 10.1056/NEJMoa0807611 |
| Popis: | Udgivelsesdato: 2009-Jan-15 BACKGROUND: In patients with multivessel coronary artery disease who are undergoing percutaneous coronary intervention (PCI), coronary angiography is the standard method for guiding the placement of the stent. It is unclear whether routine measurement of fractional flow reserve (FFR; the ratio of maximal blood flow in a stenotic artery to normal maximal flow), in addition to angiography, improves outcomes. METHODS: In 20 medical centers in the United States and Europe, we randomly assigned 1005 patients with multivessel coronary artery disease to undergo PCI with implantation of drug-eluting stents guided by angiography alone or guided by FFR measurements in addition to angiography. Before randomization, lesions requiring PCI were identified on the basis of their angiographic appearance. Patients assigned to angiography-guided PCI underwent stenting of all indicated lesions, whereas those assigned to FFR-guided PCI underwent stenting of indicated lesions only if the FFR was 0.80 or less. The primary end point was the rate of death, nonfatal myocardial infarction, and repeat revascularization at 1 year. RESULTS: The mean (+/-SD) number of indicated lesions per patient was 2.7+/-0.9 in the angiography group and 2.8+/-1.0 in the FFR group (P=0.34). The number of stents used per patient was 2.7+/-1.2 and 1.9+/-1.3, respectively (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|