Promising anti-diabetic effect of dextran sulfate sodium: Is it its clinical come back?

Autor:	Assaad A. Eid, Mohamed H. Noureldein, Ali I. Nabbouh, Batoul Dia
Rok vydání:	2019
Předmět:	Male Glucose utilization animal diseases Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Pharmacology digestive system 03 medical and health sciences Mice 0302 clinical medicine Endocrinology Diabetes mellitus Internal Medicine medicine Diabetes Mellitus Animals Humans Hypoglycemic Agents 030212 general & internal medicine Dextran Sulfate Sodium Stroke business.industry Dextran Sulfate General Medicine Diabetic retinopathy medicine.disease digestive system diseases carbohydrates (lipids) stomatognathic diseases Mechanism of action medicine.symptom Plasma insulin business Complication
Zdroj:	Diabetes research and clinical practice. 159
ISSN:	1872-8227
Popis:	Clinical studies showed that dextran sulfate sodium (DSS) alleviates stroke, diabetic retinopathy and hypercholesterolemia, yet its mechanism of action was unrevealed. This study show that DSS reduces hyperglycemia, plasma insulin and enhances glucose utilization by attenuating ROS production, suggesting a novel therapeutic use of DSS in diabetes and its complication.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ffa4527d6f3607a6b21fa010525dd7 https://pubmed.ncbi.nlm.nih.gov/30880091 Zobrazit plný text záznamu Full Text from ScienceDirect