Changes in Complement Levels and Activity of Red Blood Cells, Fresh Frozen Plasma, and Platelet Concentrates During Storage

Autor: Leiying Zhang, Shufang Wang, Yang Liu, Yang Yu, Ping Di, Jinghua Sun, Hongfei Zhang, Deqing Wang, Xiaomin Liu, Yingwei Song, Ruoshuai Cui
Rok vydání: 2020
Předmět:
Zdroj: Indian J Hematol Blood Transfus
ISSN: 0974-0449
0971-4502
DOI: 10.1007/s12288-020-01338-0
Popis: Complement cascade plays an important role in the field of transfusion medicine. The study aimed to detect the complement levels of different blood components and different blood types to explore the risk of transfusion of stored blood. The samples including red blood cells (n = 110), fresh frozen plasma (n = 120), and platelet concentrates (n = 104) from healthy blood donors in our center were collected. Complement components (C3, C4, C3b, C3d, and CH50) were assayed to evaluate the activation of complement. The complement levels of various blood components at different storage times were observed. The differences in complement levels of four blood types in various blood components were compared. The complement levels of red blood cells in storage were low, with no significant changes (P > 0.05). C3b and C3d levels in platelets began to significantly increase after storage for 3 days (P 0.05), but the C3b and C3d levels of AB fresh frozen plasma remained stable during storage, which different from other blood types. The transfusion of red blood cells was relatively safe in terms of complement activation. The activation of complement proteins occurred during the storage of platelet and plasma, except group AB plasma. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12288-020-01338-0) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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