Simple Amides of Oleanolic Acid as Effective Penetration Enhancers
| Autor: | Lucjusz Zaprutko, Danuta Partyka, Barbara Bednarczyk-Cwynar |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Multidisciplinary
Skin Absorption Chemical structure lcsh:R lcsh:Medicine Membranes Artificial Penetration (firestop) Amides Combinatorial chemistry Permeability Ointments chemistry.chemical_compound Promoter activity Biochemistry chemistry Skin penetration Drug delivery lcsh:Q Oleanolic Acid lcsh:Science Enhancer Oleanolic acid Progesterone Research Article Transdermal |
| Zdroj: | PLoS ONE, Vol 10, Iss 5, p e0122857 (2015) PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0122857 |
| Popis: | Transdermal transport is now becoming one of the most convenient and safe pathways for drug delivery. In some cases it is necessary to use skin penetration enhancers in order to allow for the transdermal transport of drugs that are otherwise insufficiently skin-permeable. A series of oleanolic acid amides as potential transdermal penetration enhancers was formed by multistep synthesis and the synthesis of all newly prepared compounds is presented. The synthetized amides of oleanolic acid were tested for their in vitro penetration promoter activity. The above activity was evaluated by means of using the Fürst method. The relationships between the chemical structure of the studied compounds and penetration activity are presented. |
| Databáze: | OpenAIRE |
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