Actual long-term survival in HCC patients with portal vein tumor thrombus after liver resection: a nationwide study

Autor: Minshan Chen, Jian-Hua Lin, Tian-Fu Wen, Yangqing Huang, Jing Li, Xiu-Ping Zhang, Zhen-Hua Chen, Shu-Qun Cheng, Yu Zhang, Yufu Tang, Yu-Gang Lu, Cheng-Qian Zhong, Fan Zhang, Dong Zhou, Xiao-Jing Wu, Jie Shi, Wei-Xing Guo, Ding-Hua Yang, Yi-Jun Xia, Rui-Fang Fan, Yi-Ren Hu, L.-Q. Li, Wei-Dong Jia, Zuo-Jun Zhen, Joseph Lau
Rok vydání: 2020
Předmět:
Zdroj: Hepatology International. 14:754-764
ISSN: 1936-0541
1936-0533
DOI: 10.1007/s12072-020-10032-2
Popis: Liver resection for hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) offers a chance of cure, although survival is often limited. The actual 3-year survival and its associated prognostic factors have not been reported. A nationwide database of HCC patients with PVTT who underwent liver resection with ‘curative’ intent was analyzed. The clinicopathologic characteristics, the perioperative, and survival outcomes for the actual long-term survivors were compared with the non-long-term survivors (patients who died within 3 years of surgery). Univariable and multivariable regression analyses were performed to identify predictive factors associated with long-term survival outcomes. The study included 1590 patients with an actuarial 3-year survival of 16.6%, while the actual 3-year survival rate was 11.7%. There were 171 patients who survived for at least 3 years after surgery and 1290 who died within 3 years of surgery. Multivariable regression analysis revealed that total bilirubin > 17.1 μmol/l, AFP > 400 ng/ml, types of hepatectomy, extent of PVTT, intraoperative blood loss > 400 ml, tumor diameter > 5 cm, tumor encapsulation, R0 resection, liver cirrhosis, adjuvant TACE, postoperative early recurrence (
Databáze: OpenAIRE
Externí odkaz: