Towards a microfluidics platform for the continuous manufacture of organic and inorganic nanoparticles
| Autor: | Vaishali Balachandran, Brennan Larkin, Diti Desai, Deepak E. Solomon, Alasdair Morton, Yadir A. Guerrero, Lisa Lyon |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Computer science Microfluidics Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Bioengineering Nanotechnology 02 engineering and technology Microfluidic Analytical Techniques 021001 nanoscience & nanotechnology Cosmeceuticals Nanomaterials 03 medical and health sciences Lab-On-A-Chip Devices Molecular Medicine Nanoparticles General Materials Science 0210 nano-technology Inorganic nanoparticles 030304 developmental biology |
| Zdroj: | Nanomedicine : nanotechnology, biology, and medicine. 35 |
| ISSN: | 1549-9642 |
| Popis: | In the last decade, microfluidics has opened new avenues for the synthesis of nanomaterials. However, the adoption of this production technique has been limited to a few high-value, low-production-volume organic nanoparticles. While there are several technical factors that can be attributed to this slow adoption, an important aspect to consider is the lack of a unified platform capable of producing a wide range of nanomaterials. In this work, we highlight a micro-mixing platform that can manufacture both organic and in-organic nanoparticles over a wide size range (nm-μm). We show that the platform can predictably and reproducibly create size and shape-controlled formulations with high homogeneity through input flow parameters. We further explore parallelization of this platform and discuss key technical constraints for high-volume production. We believe that the platform presented in this work can accelerate the adoption of nanomaterials relevant to a range of industries that encompass pharmaceutics, diagnostics, and cosmeceuticals. |
| Databáze: | OpenAIRE |
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