Long-term sex selective hormonal and behavior alterations in mice exposed to low doses of chlorpyrifos in utero
| Autor: | Julia A. Haviland, Warren P. Porter, Daniel E. Butz |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Insecticides Thyroid Hormones medicine.medical_specialty Ratón Gestational Age Biology Toxicology Mice chemistry.chemical_compound Sex Factors Pregnancy Internal medicine medicine Animals Radial arm maze Behavior Animal Organophosphate Thyroxine Endocrinology chemistry In utero Prenatal Exposure Delayed Effects Chlorpyrifos Toxicity Triiodothyronine Gestation Female Hormone |
| Zdroj: | Reproductive Toxicology. 29:74-79 |
| ISSN: | 0890-6238 |
| DOI: | 10.1016/j.reprotox.2009.10.008 |
| Popis: | Chlorpyrifos, O,O-diethyl-O-(3,5,6-trichloro-2-pyridyl) phosphorothioate, is an organophosphate insec- ticide known to be present in human urine. In utero exposure to chlorpyrifos may cause long-term hormonal and behavior alterations. In this study mice were exposed to 0, 1 or 5 mg/kg chlorpyrifos on gestational days 17-20. In utero exposed mice were then tested in a novel foraging behavior maze and assayed for thyroid hormones. Free Thyroxine Index increased significantly in females, but not males. Learning latency and reduced learning ability was evident during training sessions 5-9 in female mice exposed to 1 or 5 mg/kg chlorpyrifos. No learning deficiencies were observed in male mice. No differ- ences were seen in behavior when using a standard radial arm maze during the nine training sessions. These data suggest that mice are susceptible to neuro-endocrine reprogramming by chlorpyrifos, and demonstrate the efficacy of the novel foraging maze as an efficient behavior assay tool. |
| Databáze: | OpenAIRE |
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