Assessment of Mean Platelet Volume in Patients with AA Amyloidosis and AA Amyloidosis Secondary to Familial Mediterranean Fever: A Retrospective Chart - Review Study
| Autor: | Alihan Oral, Ali Bakan, Ali Riza Odabas, Recep Demirci, Gulsah Şaşak Kuzgun, Kübra Aydın Bahat, Omer Celal Elcioglu, Sabahat Alışır Ecder |
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| Přispěvatelé: | ELÇİOĞLU, Ömer Celal |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Turkey Familial Mediterranean fever Blood Sedimentation Disease 030204 cardiovascular system & hematology Kidney Gastroenterology Leukocyte Count 03 medical and health sciences 0302 clinical medicine AA amyloidosis Clinical Research Albumins Internal medicine Chart review A Retrospective Chart - Review Study- MEDICAL SCIENCE MONITOR cilt.25 ss.3854-3859 2019 [BAKAN A. Oral A. ECDER S. A. KUZGUN G. S. Elcioglu O. C. demirci R. Bahat K. A. ODABAS A. R. -Assessment of Mean Platelet Volume in Patients with AA Amyloidosis and AA Amyloidosis Secondary to Familial Mediterranean Fever] medicine Humans In patient Mean platelet volume Aged Retrospective Studies Proteinuria Platelet Count business.industry Amyloidosis General Medicine Middle Aged Prognosis medicine.disease Familial Mediterranean Fever C-Reactive Protein 030220 oncology & carcinogenesis Female medicine.symptom business Mean Platelet Volume |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| Popis: | BACKGROUND Amyloidosis is a protein-misfolding disease characterized by the deposition of aggregated proteins in the form of abnormal fibrils that disrupt tissue structure, ultimately causing disease. Amyloidosis is very frequent in untreated familial Mediterranean fever (FMF) patients and it is the most important feature that determines the prognosis of FMF disease. The mean platelet volume (MPV) in FMF has been previously studied. However, whether MPV level in FMF patients is lower or higher compared to healthy controls remains a topic of ongoing debate. In this study, we aimed to investigate MPV values and to assess the correlation between MPV and proteinuria in patients with AA amyloidosis and AA amyloidosis secondary to familial Mediterranean fever (AA-FMF) through a retrospective chart-review. MATERIAL AND METHODS This study was carried out on 27 patients with AA amyloidosis, 36 patients with AA amyloidosis secondary to FMF (a total of 63 patients with AA), and 29 healthy controls. There was no statistically significant difference between the AA patients and the control group (p=0.06) or between the AA-FMF group and the control group in terms of MPV values (p=0.12). RESULTS We found a statistically significant negative correlation between MPV and thrombocyte count in all groups (p |
| Databáze: | OpenAIRE |
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