Comparing drug effectiveness in children: A systematic review
| Autor: | Miriam C. J. M. Sturkenboom, Carmen Ferrajolo, Osemeke U. Osokogu, Krupa Patel, Julijana Dukanovic |
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| Přispěvatelé: | Medical Informatics, Dukanovic, Julijana, Osokogu, Osemeke U., Patel, Krupa, Ferrajolo, Carmen, Sturkenboom, Miriam C. J. M. |
| Rok vydání: | 2018 |
| Předmět: |
Drug
medicine.medical_specialty Comparative Effectiveness Research pharmacoepidemiology Epidemiology media_common.quotation_subject Comparative effectiveness research review MEDLINE 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Medicine Humans Pharmacology (medical) Statistical analysis 030212 general & internal medicine Child Propensity Score media_common business.industry Confounding Infant Newborn Pharmacoepidemiology Anti-Bacterial Agents Observational Studies as Topic pediatric Treatment Outcome Research Design Propensity score matching Emergency medicine Anticonvulsants business Cohort study Antipsychotic Agents |
| Zdroj: | Pharmacoepidemiology and Drug Safety, 27(12), 1295-1301. John Wiley & Sons Ltd. |
| ISSN: | 1053-8569 |
| Popis: | Purpose: The purpose of the study is to assess the current state of the art in pediatric comparative effectiveness research, potential gaps, and areas for improvement. Methods: Relevant articles from inception to February 2015 were retrieved from Embase and Medline. We sequentially screened titles, abstracts, and full texts, with independent validation. Data regarding general information and study methods including statistical analysis were extracted. Study quality was assessed using Newcastle-Ottawa Scale (NOS). Investigated drugs were ranked and compared with data on the prevalence of pediatric drug use. Results: Three thousand nine hundred twenty-six abstracts were screened for eligibility and inclusion, and 164 articles were included in the review. Most studies were from North America (46.7%). Only 78 studies (47.6%) reported the design: 90.8% were cohort studies. Neonates were least frequently investigated. The drugs that were most often studied included systemic antibacterials (11.4%), psycholeptics (7.9%), and antiepileptics (7.6%). Adjustment for confounding was made using propensity scores in 8.5% of the studies. Studies that did not report the design were of lower quality. Many effectiveness studies were done on antineoplastic agents, which are not frequently used and few studies on analgesics and drugs for obstructive airway diseases which are frequently prescribed. Conclusions: There is ample opportunity to improve comparative effectiveness research for drugs used in pediatrics. Routinely prescribed drugs were seldom investigated. Modern methods for confounding adjustment, such as propensity scores, were rarely used. |
| Databáze: | OpenAIRE |
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