Usefulness of Positron Emission Tomography in the Examination of Hilar and Mediastinal Lymphadenopathies in Patients with Suspicion of Lung Cancer

Autor: José Martín Carreira-Villamor, Antonio Miguel Golpe-Sánchez, Antonio Golpe-Gómez, Alberto Ruano-Ravina, Anxo Martínez de Alegría, Luis Valdés, Tara Pereiro-Brea
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Pulmonary and Respiratory Medicine
Male
medicine.medical_specialty
Comparative Effectiveness Research
Lung Neoplasms
Article Subject
Biopsy
Lymphadenopathy
Standardized uptake value
Sensitivity and Specificity
03 medical and health sciences
Diseases of the respiratory system
0302 clinical medicine
Predictive Value of Tests
medicine
Humans
Lung cancer
Aged
Neoplasm Staging
Retrospective Studies
medicine.diagnostic_test
RC705-779
business.industry
Patient Selection
Mediastinum
Retrospective cohort study
Histology
Gold standard (test)
medicine.disease
medicine.anatomical_structure
030228 respiratory system
Positron emission tomography
Spain
030220 oncology & carcinogenesis
Radiological weapon
Lymphatic Metastasis
Positron-Emission Tomography
Female
Radiology
business
Tomography
X-Ray Computed
Research Article
Zdroj: Canadian Respiratory Journal
Canadian Respiratory Journal, Vol 2020 (2020)
ISSN: 1916-7245
1198-2241
Popis: Introduction. Lung cancer is a major health problem. Mediastinal staging performed with the aid of imaging techniques is essential for appropriate disease treatment and prognosis. Accordingly, this study aimed to ascertain the usefulness of positron emission tomography (PET) in mediastinal staging, establish the best maximum standardized uptake value (SUVmax) cutoff point, compare its usefulness to that of computed tomography (CT), and determine the influence of histological tumour subtype. Methods. We conducted a retrospective study across a period of 3 years on 128 patients with suspicion of lung cancer and analyzed their demographic and radiological characteristics using CT and PET to perform the mediastinal examination. Histology was regarded as the gold standard. Results. PET displayed a high sensitivity (95%) and negative predictive value (NPV) (92%), outperforming CT (89% and 85%, respectively). Percentage agreement with histology was also higher (0.207 and 0.241 for CT and PET, respectively; p<0.001). Taking an SUVmax value of 0.5 as that which would ensure greatest diagnostic accuracy, S and NPV were 100%, though percentage agreement did not increase (0.189; p<0.001). PET discriminatory power was not affected by histological tumour subtype. Conclusions. The results of our study indicate that PET might be a useful test for examination of the mediastinum in lung cancer patients. Its high NPV suggests that the absence of mediastinal uptake could be used to proceed to surgical treatment without the need for further tests or examinations. Nevertheless, studies directly aimed to answer this specific question are needed.
Databáze: OpenAIRE
Externí odkaz: