Dopamine D1 and D2 receptor binding sites in brain samples from depressed suicides and controls
| Autor: | Andreas E. Theodorou, Cornelius Katona, Christine Bowden, Sharon C. Cheetham, M. Rufus Crompton, Sandra Lowther, Roger W. Horton |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Poison control Violence Nucleus accumbens Reference Values Dopamine Dopamine receptor D2 Internal medicine medicine Humans Receptor Molecular Biology Aged Raclopride Binding Sites Depression Receptors Dopamine D2 Receptors Dopamine D1 General Neuroscience Putamen Brain Middle Aged Antidepressive Agents Suicide Endocrinology Anesthesia Antidepressant Female Neurology (clinical) Psychology Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 752:227-233 |
| ISSN: | 0006-8993 |
| Popis: | Dopamine D1 and D2 receptors were measured (by saturation binding of [3H]SCH23390 and [3H]raclopride) in caudate, putamen and nucleus accumbens, obtained at post-mortem from suicide victims with a firm retrospective diagnosis of depression and matched controls. There were no differences in the number or affinity of D1 or D2 receptors between suicides who had been free of antidepressants for at least three months prior to death, and controls. Increased numbers and decreased affinity of D2 receptors were however found in each brain region of antidepressant-treated suicides. We argue that these increases are related to concurrent treatment with neuroleptics rather than a direct effect of antidepressants. Increased numbers of D1 receptors in antidepressant-treated suicides were seen only in nucleus accumbens. This increase could not be clearly attributed to neuroleptics and may be related to antidepressant treatment. |
| Databáze: | OpenAIRE |
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