Impact of initial antibiotic choice and delayed appropriate treatment on the outcome of Staphylococcus aureus bacteremia
| Autor: | S. Saeed, Riad Khatib, M. G. Fakih, K. Riederer, Mamta Sharma, L. B. Johnson |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Microbiology (medical) Staphylococcus aureus medicine.medical_specialty Time Factors Micrococcaceae medicine.drug_class Antibiotics Bacteremia Microbial Sensitivity Tests beta-Lactams medicine.disease_cause Drug Administration Schedule chemistry.chemical_compound Medical microbiology Vancomycin Internal medicine medicine Humans Antibacterial agent biology business.industry General Medicine Middle Aged Staphylococcal Infections biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification medicine.disease Anti-Bacterial Agents Surgery Treatment Outcome Infectious Diseases chemistry Linezolid Female Methicillin Resistance business medicine.drug |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases. 25:181-185 |
| ISSN: | 1435-4373 0934-9723 |
| DOI: | 10.1007/s10096-006-0096-0 |
| Popis: | The study presented here investigated the impact of initial antibiotic choice (beta-lactams vs vancomycin) on the outcome of 342 patients with Staphylococcus aureus bacteremia (50.9% with methicillin-resistant isolates) encountered between 1 January 2002 and 30 June 2003. Initial antibiotics were inappropriate (beta-lactams) in 60 (34.5%) methicillin-resistant cases and suboptimal (vancomycin) in 62 (36.9%) methicillin-susceptible cases. Time to effective antibiotic therapy was longer in methicillin-resistant cases (25.5+/-28.6 vs 9.6+/-16.6 h; p0.0005). All-cause in-hospital mortality was higher with inappropriate therapy (35.0 vs 20.9%; p=0.02). Initial vancomycin treatment was associated with a higher incidence of delayed clearance (or=3 days) of methicillin-susceptible bacteremia (56.3 vs 37.0%; p=0.03). The results indicate inappropriate initial therapy is associated with higher in-hospital mortality and initial vancomycin may delay clearance. |
| Databáze: | OpenAIRE |
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