SUCCESSFUL TREATMENT OF A CLINICAL ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS INFECTION: THE DYNAMICS OF VIRAL LOAD, GENOTYPE ANALYSIS, AND TREATMENT WITH ACYCLOVIR
| Autor: | Taweepoke Angkawanish, William Ditcham, Supaphen Sripiboon, Kristin S. Warren, Khajohnpat Boonprasert, Petthisak Sombutputorn, Warangkhana Langkaphin |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Genotype 040301 veterinary sciences medicine.drug_class viruses Elephants Antibiotics Acyclovir Antiviral Agents Virus 0403 veterinary science 03 medical and health sciences Asian elephant medicine Animals Aciclovir Herpesviridae Phylogeny General Veterinary business.industry Herpesviridae Infections 04 agricultural and veterinary sciences General Medicine Viral Load Virology 030104 developmental biology Real-time polymerase chain reaction Animal Science and Zoology business Complication Viral load medicine.drug |
| Zdroj: | Journal of Zoo and Wildlife Medicine. 48:1254-1259 |
| ISSN: | 1937-2825 1042-7260 |
| Popis: | This article describes the treatment of clinical elephant endotheliotropic herpesvirus (EEHV) infection in a male Asian elephant (Elephas maximus; approximately 3 yr old), the dynamics of viral load during the active infection, and genetic analysis of the virus. Treatment included injectable acyclovir (12 mg/kg iv, bid), antibiotic, vitamin, and fluids. Quantitative polymerase chain reaction was used to measure the viral levels in blood, which decreased continuously after initiation of intravenous acyclovir. Low levels of virus were detected in the blood for 2 wk, and the virus was undetectable after 1 mo. No complication was observed during the treatment period. This case report suggests that acyclovir, given parenterally, could potentially enhance survival of clinical EEHV-infected individuals. |
| Databáze: | OpenAIRE |
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