Immune response to ultraviolet-induced tumors. I. Transplantation immunity developing in syngeneic mice in response to progressor ultraviolet-induced tumors
| Autor: | Fortner Gw, Lill Ph |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Neoplasms
Radiation-Induced Ratón Ultraviolet Rays Fibrosarcoma Mice Nude Cell Line Epitopes Mice Immune system Antigen In vivo Immunity Antigens Neoplasm Transplantation Immunology Cytotoxic T cell Animals Ascitic Fluid Transplantation Mice Inbred C3H Antitumor immunity Chemistry Immunization Passive Neoplasm Regression Spontaneous Immunology Spleen T-Lymphocytes Cytotoxic |
| Zdroj: | Transplantation. 39(1) |
| ISSN: | 0041-1337 |
| Popis: | Ultraviolet-light-induced murine skin tumors were analyzed for the ability to induce transplantation immunity and cytotoxic lymphocytes in syngeneic mice. A correlation was found between tumor regression and the induction of cytotoxic T cells with specificity for a unique tumor-associated antigen. Processing tumors possessed tumor-associated transplantation antigens (TATA), which could be demonstrated by transplantation in hyperimmunized mice. Progression correlated with a lack of splenic cytotoxic T cell reactivity. High levels of in situ cytotoxic reactivity could be induced by presenting the tumor-specific antigen on nongrowing tumor cells. Tumor-bearer hosts were shown to be sensitized to TATA because cultured tumor-bearer T cells adoptively transferred protection against tumor outgrowth. Mechanisms of the in vivo suppression of antitumor immunity are discussed. |
| Databáze: | OpenAIRE |
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