Accurate Depth of Radiofrequency-Induced Lesions in Renal Sympathetic Denervation Based on a Fine Histological Sectioning Approach in a Porcine Model
| Autor: | Hitomi Hagiwara, Kiyoshi Matsumura, Toshihito Furukawa, Atsushi Sakaoka, Kenichi Sakakura, Shintaro Nakamura, Hisako Terao |
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| Rok vydání: | 2017 |
| Předmět: |
Sympathetic Nervous System
Time Factors medicine.medical_treatment Sus scrofa Catheter ablation 030204 cardiovascular system & hematology Kidney 03 medical and health sciences 0302 clinical medicine medicine.artery medicine Animals 030212 general & internal medicine Renal artery Sympathectomy Denervation electric impedance renal artery denervation business.industry Temperature Original Articles Ablation Lesion depth electrodes medicine.anatomical_structure Peripheral Vascular Disease Renal sympathetic denervation Models Animal Catheter Ablation Female pathology Cardiology and Cardiovascular Medicine Nuclear medicine business |
| Zdroj: | Circulation. Cardiovascular Interventions |
| ISSN: | 1941-7632 |
| Popis: | Background— Ablation lesion depth caused by radiofrequency-based renal denervation (RDN) was limited to Methods and Results— Radiofrequency was delivered to 87 sites in 14 renal arteries from 9 farm pigs at various ablation settings: 2, 4, 6, and 9 W for 60 seconds and 6 W for 120 seconds. Electric impedance and electrode temperature were recorded during ablation. At 7 days, 2470 histological sections were obtained from the treated arteries. Maximum lesion depth increased at 2 to 6 W, peaking at 6.53 (95% confidence interval, 4.27–8.78) mm under the 6 W/60 s condition. It was not augmented by greater power (9 W) or longer duration (120 seconds). There were statistically significant tendencies at 6 and 9 W, with higher injury scores in the media, nerves, arterioles, and fat. Maximum lesion depth was positively correlated with impedance reduction and peak electrode temperature (Pearson correlation coefficients were 0.59 and 0.53, respectively). Conclusions— Lesion depth was 6.5 mm for radiofrequency-RDN at 6 W/60 s. The impedance reduction and peak electrode temperature during ablation were closely associated with lesion depth. Hence, these biophysical parameters could provide prompt feedback during radiofrequency-RDN procedures in the clinical setting. |
| Databáze: | OpenAIRE |
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