Enterovirus D68 disease and molecular epidemiology in Australia
| Autor: | Alfred Dofai, Jason A. Roberts, Simone Tempone, Jurissa Lang, Alison M. Kesson, Andrew J Daley, Bruce Thorley, David J. Speers, Avram Levy |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Adolescent Disease medicine.disease_cause Feces Young Adult Virology Epidemiology medicine Enterovirus Infections Humans Young adult Child Respiratory Tract Infections Phylogeny Enterovirus Paraplegia Molecular epidemiology Respiratory tract infections business.industry Respiratory disease Australia Infant medicine.disease Infectious Diseases Child Preschool Immunology Capsid Proteins Female business Sentinel Surveillance |
| Zdroj: | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 69 |
| ISSN: | 1873-5967 |
| Popis: | Background Enterovirus D68 (EV-D68) has received considerable recent attention as a cause of widespread respiratory illness. Neurological syndromes such as acute flaccid paralysis following EV-D68 infection have also been reported in a small number of cases. Objectives To summarize the clinical and epidemiological characteristics of laboratory confirmed EV-D68 cases in Australia. Study design We combined EV-D68 data acquired through laboratory surveillance in Western Australia with cases from national enterovirus surveillance and regional acute flaccid paralysis (AFP) surveillance. Clinical data was obtained for EV-D68 cases and capsid protein sequences were used for phylogenetic analysis. Results Sporadic cases of EV-D68 were recorded in Australia since 2008, with peaks in activity during 2011 and 2013. EV-D68 was primarily associated with respiratory disease, but was also detected in cerebrospinal fluid of one patient and faeces of two patients presenting with AFP. Conclusions EV-D68 has been circulating in Western Australia and is likely to have also been present in the wider region for a number of years, causing primarily respiratory disease. Detection of EV-D68 in cerebrospinal fluid of one patient and in faeces of two AFP cases reinforces the association between EV-D68 and neurological disease. |
| Databáze: | OpenAIRE |
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