Prevalence of JC Virus Viraemia in HIV-Infected Patients with or Without Neurological Disorders: A Prospective Study
| Autor: | Claudine Buffet Janvresse, Amina Karaterki, Annick Ruffault, Helene Moret, Didier Ingrand, Elisabeth Dussaix, Yacine Taoufik, Véronique Dubois, Marie-Edith Lafon, Catherine Vignoli, Josette Icart |
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| Rok vydání: | 1998 |
| Předmět: |
viruses
Central nervous system JC virus HIV Infections Genome Viral medicine.disease_cause Polymerase Chain Reaction Cellular and Molecular Neuroscience Virology Leukocytes Prevalence medicine Demyelinating disease Humans Hiv infected patients Prospective Studies Viremia Prospective cohort study business.industry Progressive multifocal leukoencephalopathy Papillomavirus Infections Leukoencephalopathy Progressive Multifocal virus diseases Prognosis medicine.disease JC Virus Predictive value Pathophysiology CD4 Lymphocyte Count nervous system diseases Survival Rate Blotting Southern medicine.anatomical_structure nervous system Neurology Immunology France Neurology (clinical) business |
| Zdroj: | Journal of Neurovirology. 4:539-544 |
| ISSN: | 1538-2443 1355-0284 |
| DOI: | 10.3109/13550289809113498 |
| Popis: | Progressive Multifocal Leukoencephalopathy (PML) is a severe demyelinating disease, which is rapidly fatal and is due to JC virus (JCV) infection, which especially occurs in HIV-infected patients. To investigate JCV pathophysiology and to evaluate the predictive value of JCV detection in blood, we looked for JCV DNA in leukocytes and plasma of 96 patients without any neurological symptoms and 109 patients with neurological diseases, among whom 19 were suffering from PML. JCV genome was detected in about 18% of all patients, i.e. 15.6% of patients with central nervous system disorders except PML, 13.5% of patients without neurological symptoms and significantly more often in PML patients (47.6%). Both leukocytes and plasma were tested; in plasma, JCV DNA was found in 36.1% of positive patients and in cells in 80.5%. Surprisingly in seven instances only the plasma contained JCV genome. One-year follow-up of these patients showed that the absence of JCV DNA in blood was associated with a very low probability of developing PML (negative predictive value=0.99). |
| Databáze: | OpenAIRE |
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