GenoBase: comprehensive resource database of Escherichia coli K-12
| Autor: | Rikiya Takeuchi, Barry L. Wanner, Hitomi Dose, Barry R. Bochner, Hirotada Mori, Tyrrell Conway, Shigeki Tanishima, Walid G. Aref, Yuta Otsuka, Ai Muto, Yukako Tohsato, Wataru Nomura, Chihiro Okada, Daisuke Kihara, Michael Gribskov, Toru Nakayashiki, Kenneth E. Rudd, Motokazu Ishikawa, Natsuko Yamamoto, Koichiro Nakamura, Kenji Nakahigashi, Sivasundaram Suharnan |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Genetics
0303 health sciences Internet Deletion mutant Escherichia coli K12 030306 microbiology Escherichia coli Proteins Molecular Sequence Annotation Computational biology Biology Omics data 03 medical and health sciences Annotation Resource (project management) Genes Bacterial Databases Genetic Mutation Key (cryptography) Academic community Database Issue ORFeome Functional genomics Genome Bacterial 030304 developmental biology |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 |
| Popis: | Comprehensive experimental resources, such as ORFeome clone libraries and deletion mutant collections, are fundamental tools for elucidation of gene function. Data sets by omics analysis using these resources provide key information for functional analysis, modeling and simulation both in individual and systematic approaches. With the long-term goal of complete understanding of a cell, we have over the past decade created a variety of clone and mutant sets for functional genomics studies of Escherichia coli K-12. We have made these experimental resources freely available to the academic community worldwide. Accordingly, these resources have now been used in numerous investigations of a multitude of cell processes. Quality control is extremely important for evaluating results generated by these resources. Because the annotation has been changed since 2005, which we originally used for the construction, we have updated these genomic resources accordingly. Here, we describe GenoBase (http://ecoli.naist.jp/GB/), which contains key information about comprehensive experimental resources of E. coli K-12, their quality control and several omics data sets generated using these resources. |
| Databáze: | OpenAIRE |
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