Feto-maternal bone remodeling in normal pregnancy and preeclampsia

Autor: Mahmoud E. Salem, Sameh Zaki, Ahmed M. El-Minawi, Abdel-Megid Ramzi, Mohamed Shaarawy
Rok vydání: 2004
Předmět:
Adult
medicine.medical_specialty
Pregnancy Trimester
Third
Osteocalcin
Osteoclasts
Enzyme-Linked Immunosorbent Assay
Urine
Collagen Type I
Bone remodeling
Preeclampsia
03 medical and health sciences
Transforming Growth Factor beta2
0302 clinical medicine
Pre-Eclampsia
Pregnancy
Transforming Growth Factor beta
Internal medicine
Medicine
Humans
Bone Resorption
Maternal-Fetal Exchange
Fetus
030219 obstetrics & reproductive medicine
Membrane Glycoproteins
biology
Receptor Activator of Nuclear Factor-kappa B
business.industry
Interleukin-6
Tumor Necrosis Factor-alpha
RANK Ligand
Infant
Newborn
Obstetrics and Gynecology
Venous blood
medicine.disease
Fetal Blood
Endocrinology
Cord blood
Case-Control Studies
Infant
Small for Gestational Age
biology.protein
Gestation
Female
Collagen
business
Carrier Proteins
Peptides
030217 neurology & neurosurgery
Zdroj: Journal of the Society for Gynecologic Investigation. 12(5)
ISSN: 1556-7117
Popis: To investigate feto-maternal bone turnover in normal pregnancy and preeclampsia and to test the hypothesis whether the reported low bone mass at birth in small-for-gestational age infants is associated with decreased bone formation or increased bone resorption.Thirty-two patients with preeclampsia (17 mild and 15 severe) and 20 normotensive women (controls) with singleton gestations in the third trimester participated in this study. Furthermore, 25 nonpregnant healthy women were chosen as nonpregnant controls. Maternal 24-hour urine specimens and venous blood samples were collected. In addition, fetal cord blood and the first voided neonatal urine were also collected. The freshly separated sera were assayed for osteocalcin (OC) and carboxy-terminal propeptide of type 1 collagen (PICP) by radioimmunoassay. Urine samples were assayed for N-telopeptide of type 1 collagen (NTx) by enzyme-linked immunosorbent assay.Maternal and cord serum OC and PICP levels were significantly decreased in severe preeclampsia, whereas maternal and first-voided neonatal urinary NTx level were significantly increased compared to the corresponding levels of controls. In both mother and fetus, the coupling index of markers of bone turnover in normal pregnancy or mild preeclampsia was in favor of bone formation, whereas in severe preeclampsia the markers suggested marked bone resorption.Increased bone resorption and decreased bone formation occur in preeclampsia in both mother and fetus, being more pronounced in the latter. The increased osteoclastic activity in preeclampsia may be attributed to increased RANKL induced by increased interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor beta2 (TGF-beta2) production.
Databáze: OpenAIRE
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