Immunomodulatory Lectin-like Peptides for Fish Erythrocytes-Targeting as Potential Antiviral Drug Delivery Platforms
| Autor: | Salvador-Mira, Maria, Chico, Veronica, Arostica, Mónica, Guzmán, Fanny, Roher Armentia, Nerea, Perez Garcia-Estañ, Luis, Ortega-Villaizan, Maria del Mar, Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Erythrocytes
Cell Pharmacology Red blood cells ligand cell-targeting Drug Delivery Systems 0302 clinical medicine Lectins Biology (General) Spectroscopy media_common 0303 health sciences biology Communication Cell-targeting General Medicine Ligand (biochemistry) peptide 3. Good health Computer Science Applications Erythrocyte Chemistry medicine.anatomical_structure Oncorhynchus mykiss 030220 oncology & carcinogenesis prophylactic Drug delivery Peptide Therapeutic Fish Proteins Drug medicine.drug_class QH301-705.5 media_common.quotation_subject Ligand Antiviral Agents Catalysis Prophylactic Inorganic Chemistry 03 medical and health sciences Immune system medicine Animals Physical and Theoretical Chemistry Molecular Biology QD1-999 030304 developmental biology fish Organic Chemistry Plasmodium falciparum biology.organism_classification therapeutic Fish Membrane protein drug delivery lectin erythrocyte Antiviral drug Peptides Lectin red blood cells |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 11821, p 11821 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Altres ajuts: Generalitat Valenciana APE/2021/022 One of the challenges of science in disease prevention is optimizing drug and vaccine delivery. Until now, many strategies have been employed in this sector, but most are quite complex and labile. To overcome these limitations, great efforts are directed to coupling drugs to carriers, either of natural or synthetic origin. Among the most studied cell carriers are antigen-presenting cells (APCs), however, red blood cells (RBCs) are positioned as attractive carriers in drug delivery due to their abundance and availability in the body. Furthermore, fish RBCs have a nucleus and have been shown to have a strong involvement in modulating the immune response. In this study, we evaluated the binding of three peptides to rainbow trout RBCs, two lectin-like peptides and another derived from Plasmodium falciparum membrane protein, in order to take advantage of this peptide-RBCs binding to generate tools to improve the specificity, efficacy, immunostimulatory ef-fect, and safety of the antiviral therapeutic or prophylactic administration systems currently used. |
| Databáze: | OpenAIRE |
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