Early prevention of cognitive impairment in the community population: The Beijing Aging Brain Rejuvenation Initiative
| Autor: | Qing Guan, Qingshan Wang, Kewei Chen, Ruixue Cui, Lin Ai, Junying Zhang, Caishui Yang, Zhen Liu, Yongyan Wang, Ying Liang, Jun Wang, Fang Wang, Wei Zhang, Xiaomin Wang, Xin Li, Jizong Zhao, Qi Dong, He Li, Yanping Wang, Ni Shu, Peng Lu, Dongfeng Wei, Zhanjun Zhang, Dantao Peng, Jianjun Jia, Yaojing Chen, Wuhai Tao |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Gerontology Male Longitudinal study Aging China Epidemiology Neuroimaging Cohort Studies 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Developmental Neuroscience Beijing Alzheimer Disease mental disorders Medicine Dementia Aging brain Humans Cognitive Dysfunction Longitudinal Studies Aged business.industry Health Policy Middle Aged medicine.disease Cognitive training Clinical trial Psychiatry and Mental health 030104 developmental biology Cross-Sectional Studies Disease Progression Female Neurology (clinical) Geriatrics and Gerontology business 030217 neurology & neurosurgery Cohort study |
| Zdroj: | Alzheimer'sdementia : the journal of the Alzheimer's AssociationREFERENCES. 17(10) |
| ISSN: | 1552-5279 |
| Popis: | Facing considerable challenges associated with aging and dementia, China urgently needs an evidence-based health-care system for prevention and management of dementia. The Beijing Aging Brain Rejuvenation Initiative (BABRI) is a community-based cohort study initiated in 2008 that focuses on asymptomatic stages of dementia, aims to develop community-based prevention strategies for cognitive impairment, and provides a platform for scientific research and clinical trials. Thus far, BABRI has recruited 10,255 participants (aged 50 and over, 60.3% female), 2021 of whom have been followed up at least once at a 2- or 3-year interval. This article presents aims and study design of BABRI; summarizes preliminary behavioral and neuroimaging findings on mild cognitive impairment (MCI) and results of clinical trials on MCI; and discusses issues concerning early prevention in community, MCI diagnosis methods, and applications of database of aging and dementia. BABRI is proposed to build a systematic framework on brain health in old age. |
| Databáze: | OpenAIRE |
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