Evaluation of serum Angiopoietin-like protein 2 (ANGPTL-2), Angiopoietin-like protein 8 (ANGPTL-8), and high-sensitivity C-reactive protein (hs-CRP) levels in patients with gestational diabetes mellitus and normoglycemic pregnant women
| Autor: | Baris Onder Pamuk, Zeynep Seyhanli, Saliha Aksun, Ahmet Seyhanli |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
0301 basic medicine medicine.medical_specialty Adolescent Peptide Hormones 03 medical and health sciences 0302 clinical medicine Pregnancy Angiopoietin-Like Protein 8 Angiopoietin-like Protein Internal medicine Humans Insulin Medicine In patient Angiopoietin-Like Protein 2 biology business.industry C-reactive protein Obstetrics and Gynecology medicine.disease Lipids Gestational diabetes Diabetes Gestational C-Reactive Protein 030104 developmental biology Endocrinology 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health biology.protein Female Pregnant Women Insulin Resistance business |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 35:5647-5652 |
| ISSN: | 1476-4954 1476-7058 |
| Popis: | In the present study, we aimed to investigate the role of the fasting serum levels of Anjiopoetın 2 - like protein (ANGPTL2), Anjiopoetın 8-like protein (ANGPTL8), and high-sensitivity C-reactive protein (hs-CRP) in the etiopathogenesis of gestational diabetes mellitus (GDM), and analyze the relationships between insulin resistance parameters.The 90 individuals admitted to İzmir Katip Celebi University Hospital Internal Medicine, Endocrinology and Obstetrics, and gynecology outpatient clinic were included in the study of similar ages and similar demographic characteristics. Forty-five women with diet-controlled GDM and 45 women with normoglycemic pregnancy were enrolled. ANGPTL-2, ANGPTL-8, hs-CRP, creatinine, ALT, GGT, lipid profile, HBA1c(%), and serum insülin, c-peptide levels were studied in the fasting serum samples of research groups. All individuals had 75-g OGTT testing. GDM screening was performed at 24-28 weeks' gestation. Exclusion criteria were as follows: Age18 years or40 years, pregestational diabetes (type 1 or 2), drug or alcohol abuse, thyroid dysfunction, Hepatitis B, and other infectious diseases (Herpes virus, Streptococcus B carriers, Chlamydia and Candida), Thalassemia carriers or other significant medical conditions, the use of any medication that interferes with lipid or glucose metabolism that would affect glucose regulation.Forty-five women with GDM and for the control group, 45 women with normoglycemic pregnant women were identified. The mean gestational age was 30.7 (18-38) for GDM and 29.6 (24-39) for the control group. Serum ANGPTL-8 (GDM =19.5 ± 93 Control = 0.73 ± 3.78ANGPTL8 levels were significantly higher in GDM than in healthy control group. ANGPTL2 levels and hs-CRP levels were similar to the healthy control group. Elevated serum ANGPTL8 levels were correlated significantly with insulin resistance parameters, the main component of GDM pathophysiology. Our data showed that ANGPTL8 could be a new biomarker for diagnosing GDM. |
| Databáze: | OpenAIRE |
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