Pharmacologic profile of a new antiallergic compound PRD-92-Ea
| Autor: | Stewart Pb, El-Azab J |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
Ovalbumin Immunology Bradykinin Pharmacology Histamine Release chemistry.chemical_compound Oral administration Cromolyn Sodium Hypersensitivity Immunology and Allergy Medicine Potency Animals Benzopyrans Mast Cells business.industry Passive Cutaneous Anaphylaxis Degranulation Isoproterenol Biological activity General Medicine Haplorhini Macaca mulatta Asthma Rats Disease Models Animal chemistry Bronchoconstriction Serotonin medicine.symptom business Histamine |
| Zdroj: | International archives of allergy and applied immunology. 55(1-6) |
| ISSN: | 0020-5915 |
| Popis: | PRD-92-Ea [5,5-Dimethyl-11-oxo-5H, HH-(2) benzopyrano (4,3-g) (1) benzopyran-9-carboxylic acid ethanolamine], was an active antiallergic compound in rat and monkey experimental models of immediate hypersensitivity. It inhibited, in a dose-dependent manner, the rat PCA reaction after both intravenous and oral administration. It also inhibited the degranulation of rat peritoneal mast cells after antigenic challenge. PRD-92-Ea was also active in preventing bronchoconstriction in Ascaris-sensitive Rhesus monkeys after intravenous, topical and oral administration. Using chopped monkey tissues, it was found that PRD-92-Ea prevented histamine release from the respiratory mast cells, but not from the cutaneous mast cells. No reason for this dichotomy of effect is known. PRD-92-Ea showed antagonistic activity against the allergic mediators released from mast cells. In order of decreasing potency it was active against SRS-A (monkey lung), PGF2α, PGE2, serotonin, bradykinin and histamine. Apart from its antiallergic effects PRD-92-Ea had no other significant pharmacological activity. |
| Databáze: | OpenAIRE |
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