Prognostic role of plasma fibrinogen in patients with uterine leiomyosarcoma - a multicenter study
| Autor: | Stephan Polterauer, Mariella Polterauer, Alexander Reinthaller, Lukas Hefler, Christine Bekos, Thomas Brodowicz, Christoph Grimm, Edgar Petru, Daniel Reimer, Horst Koch |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Leiomyosarcoma Pathology medicine.medical_specialty education lcsh:Medicine Fibrinogen Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Biomarkers Tumor Humans In patient lcsh:Science Grading (tumors) Retrospective Studies Multidisciplinary Uterine leiomyosarcoma business.industry lcsh:R Histology Plasma levels Middle Aged Prognosis Survival Analysis Pathophysiology Tumor Burden 030104 developmental biology Multicenter study 030220 oncology & carcinogenesis Uterine Neoplasms Disease Progression lcsh:Q Female Neoplasm Grading business medicine.drug Follow-Up Studies |
| Zdroj: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017) |
| ISSN: | 2045-2322 |
| Popis: | Fibrinogen has an important pathophysiological role in tumor cell progression and development of metastases in different types of cancer. The present study aimed to evaluate the role of pre-treatment fibrinogen plasma concentrations as a biomarker for tumor biology and prognosis in patients with uterine leiomyosarcoma (ULMS). Clinical data of patients with ULMS were assessed in this multi-center study Pre-therapeutic fibrinogen plasma concentrations were evaluated. We investigated the association between fibrinogen plasma levels and clinico-pathological parameters and performed univariate and multivariable survival analyses. In total, 70 women with ULMS were included into the analysis. Mean (SD) pre-treatment fibrinogen plasma levels were 480.2 (172.3) mg/dL. Patients with advanced tumor stage, increased tumor size and higher histological grading had higher fibrinogen levels (p = 0.02, p = 0.013, and p = 0.029, respectively). In ULMS patients with increased fibrinogen levels 5-year overall survival (OS) rates were 25.0% compared to 52.9% in ULMS patients with normal fibrinogen, respectively. Univariate survival analyses revealed that elevated fibrinogen plasma levels (p = 0.030), advanced tumor stage (p p = 0.003) showed association with unfavorable OS. In multivariable analysis, histological grade (p = 0.03) and tumor stage (0.02) were independently associated with survival. Elevated fibrinogen plasma levels were associated with aggressive tumor biology and poor prognosis in women with ULMS. Fibrinogen might be useful as a novel biomarker in ULMS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|