Role of canonical Wnt signaling/ß-catenin via Dermo1 in cranial dermal cell development
| Autor: | Isaac Brownell, Thu T.H Tran, Peter C. Scacheri, Andrew Jarrell, Adrienne Welsh, Gabriel E. Zentner, Radhika P. Atit |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Mesoderm
Beta-catenin Cellular differentiation Molecular Sequence Data Cartilage metabolism Cell fate determination Mice Transcription Factor 4 medicine Animals Cell Lineage Molecular Biology beta Catenin Body Patterning Genetics Homeodomain Proteins biology Base Sequence integumentary system Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Stem Cells Skull Twist-Related Protein 1 Wnt signaling pathway Neural crest Cell Differentiation SOX9 Transcription Factor Dermis Embryo Mammalian Cell biology Repressor Proteins Wnt Proteins medicine.anatomical_structure Cartilage Enhancer Elements Genetic Catenin biology.protein Biomarkers Developmental Biology Protein Binding Signal Transduction Research Article |
| Zdroj: | Development (Cambridge, England). 137(23) |
| ISSN: | 1477-9129 0950-1991 |
| Popis: | Cranial dermis develops from cephalic mesoderm and neural crest cells, but what signal(s) specifies the dermal lineage is unclear. Using genetic tools to fate map and manipulate a cranial mesenchymal progenitor population in the supraorbital region, we show that the dermal progenitor cells beneath the surface ectoderm process canonical Wnt signaling at the time of specification. We show that Wnt signaling/β-catenin is absolutely required and sufficient for Dermo1 expression and dermal cell identity in the cranium. The absence of the Wnt signaling cue leads to formation of cartilage in craniofacial and ventral trunk regions at the expense of dermal and bone lineages. Dermo1 can be a direct transcription target and may mediate the functional role of Wnt signaling in dermal precursors. This study reveals a lineage-specific role of canonical Wnt signaling/β-catenin in promoting dermal cell fate in distinct precursor populations. |
| Databáze: | OpenAIRE |
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