LFA-1 and ICAM-1 antibody-idarubicin conjugates separately prolong murine cardiac allograft survival

Autor:	Mauro S. Sandrin, Yu Qin Li, Soong Ling, Ian F. C. McKenzie, Geoffrey A. Pietersz
Rok vydání:	2001
Předmět:	Drug Graft Rejection Immunoconjugates medicine.drug_class media_common.quotation_subject Immunology Drug Evaluation Preclinical Pharmacology Monoclonal antibody Mice Immune Tolerance Immunology and Allergy Medicine Idarubicin Animals Transplantation Homologous media_common Transplantation ICAM-1 Mice Inbred BALB C Cardiac allograft biology business.industry Graft Survival food and beverages Antibodies Monoclonal Skin Transplantation Intercellular Adhesion Molecule-1 Lymphocyte Function-Associated Antigen-1 Mice Inbred C57BL Tolerance induction biology.protein Mice Inbred CBA Heart Transplantation Antibody business Immunosuppressive Agents medicine.drug Conjugate
Zdroj:	Transplant immunology. 9(1)
ISSN:	0966-3274
Popis:	Drug antibody conjugates can enhance the activity of monoclonal antibodies (MoAb) and idarubicin-MoAb conjugates have led to tolerance induction with antibodies which are inactive when used alone. It has been reported that, in mice, antibodies to ICAM-1 and LFA-1 have to be used together to induce tolerance to cardiac allografts; here we show that these monoclonal antibodies, conjugated to idarubicin, can lead to tolerance induction to cardiac allografts when used alone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e4639441dc0a009a4a4b7a62ac472f https://pubmed.ncbi.nlm.nih.gov/11680574 Zobrazit plný text záznamu Full Text from ScienceDirect