Blockade of Renin Angiotensin System Ameliorates the Cardiac Arrhythmias and Sympathetic Neural Remodeling in Hearts of Type 2 DM Rat Model
| Autor: | Yomna M Yehya, Khaled A. Ezam, Mohamed E Sarhan, Eman M. Ibrahim, Mohamed A F E Sarhan, Abdelaziz M. Hussein, Elsayed A. Eid, Aya El-Sayed |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Sympathetic Nervous System Endocrinology Diabetes and Metabolism Blood Pressure Type 2 diabetes 030204 cardiovascular system & hematology medicine.disease_cause Diabetes Mellitus Experimental Rats Sprague-Dawley Renin-Angiotensin System Angiotensin Receptor Antagonists Electrocardiography 03 medical and health sciences Norepinephrine 0302 clinical medicine Internal medicine Diabetic cardiomyopathy Renin–angiotensin system Animals Immunology and Allergy Medicine Enalapril business.industry Arrhythmias Cardiac medicine.disease Rats Blockade Oxidative Stress 030104 developmental biology Endocrinology Losartan Diabetes Mellitus Type 2 business Oxidative stress medicine.drug |
| Zdroj: | Endocrine, Metabolic & Immune Disorders - Drug Targets. 20:464-478 |
| ISSN: | 1871-5303 |
| Popis: | Objectives:: The present study was designed to investigate the effects of renin angiotensin system (RAS) blockade on cardiac arrhythmias and sympathetic nerve remodelling in heart tissues of type 2 diabetic rats. Methods:: Thirty-two male Sprague Dawley rats were randomly allocated into 4 equal groups; a) normal control group: normal rats, b) DM group; after type 2 diabetes induction, rats received 2ml oral saline daily for 4 weeks, c) DM+ ACEi: after type 2 diabetes induction, rats were treated with enalapril (10 mg/kg, orally for 4 weeks) and d) DM+ ARBs: after type 2 diabetes induction, rats were treated with losartan (30 mg/kg, orally for 4 weeks). Results:: In type 2 diabetic rats, the results demonstrated significant prolongation in Q-T interval and elevation of blood sugar, HOMA-IR index, TC, TGs, LDL, serum CK-MB, myocardial damage, myocardial MDA, myocardial norepinephrine and tyrosine hydroxylase (TH) density with significant reduction in serum HDL, serum insulin and myocardial GSH and CAT. On the other hand, blockade of RAS at the level of either ACE by enalapril or angiotensin (Ag) receptors by losartan resulted in significant improvement in ECG parameters (Q-T), cardiac enzymes (CK-MB), cardiac morphology, myocardial oxidative stress (low MDA, high CAT and GSH) and myocardial TH density. Conclusions:: RAS plays a role in the cardiac sympathetic nerve sprouting and cardiac arrhythmias induced by type 2 DM and its blockade might have a cardioprotective effect via attenuation of sympathetic nerve fibres remodelling, myocardial norepinephrine contents and oxidative stress. |
| Databáze: | OpenAIRE |
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