Adult Hippocampal Neurogenesis in Aging and Alzheimer's Disease
| Autor: | Kelsey R. Babcock, Ashley E. Webb, John S. Page, Justin R. Fallon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Aging Neurogenesis Hippocampus Context (language use) Review Hippocampal formation Biology Environment Biochemistry 03 medical and health sciences neural stem cell 0302 clinical medicine Alzheimer Disease Genetics Memory impairment Animals Humans Cognitive decline Dentate gyrus Cell Biology Alzheimer's disease cognitive decline Neural stem cell adult neurogenesis Disease Models Animal 030104 developmental biology Neuroscience 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Stem Cell Reports |
| ISSN: | 2213-6711 |
| Popis: | Cognitive deficits associated with Alzheimer's disease (AD) severely impact daily life for the millions of affected individuals. Progressive memory impairment in AD patients is associated with degeneration of the hippocampus. The dentate gyrus of the hippocampus, a region critical for learning and memory functions, is a site of adult neurogenesis in mammals. Recent evidence in humans indicates that hippocampal neurogenesis likely persists throughout life, but declines with age and is strikingly impaired in AD. Our understanding of how neurogenesis supports learning and memory in healthy adults is only beginning to emerge. The extent to which decreased neurogenesis contributes to cognitive decline in aging and AD remains poorly understood. However, studies in rodent models of AD and other neurodegenerative diseases raise the possibility that targeting neurogenesis may ameliorate cognitive dysfunction in AD. Here, we review recent progress in understanding how adult neurogenesis is impacted in the context of aging and AD. |
| Databáze: | OpenAIRE |
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