Investigation of antibacterial, antifungal, antibiofilm, antioxidant and anticancer properties of methanol extracts of Salvia marashica İlçim, Celep & Doğan and Salvia caespitosa Montbret & Aucher ex Benth plants with medicinal importance
| Autor: | Maside Temiz Bostanci, Yusuf Ziya Kocabaş, Ali Savas Bulbul, Nilofar Zakariae, İbrahim Çelik, Hedayat Jafari, Fatih Şen, Roghayeh Esmaeili, Fatemeh Karimi, Hakan Burhan, Ramazan Bayat, Hassan Karimi-Maleh |
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| Rok vydání: | 2022 |
| Předmět: |
Antifungal Agents
Environmental Engineering Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment Salvia Candida parapsilosis Antioxidants medicine Environmental Chemistry IC50 Minimum bactericidal concentration biology Traditional medicine Plant Extracts Chemistry Methanol Public Health Environmental and Occupational Health General Medicine General Chemistry biology.organism_classification Antimicrobial Pollution Anti-Bacterial Agents MCF-7 Biofilms Bacteria |
| Zdroj: | Chemosphere. 288:132602 |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/j.chemosphere.2021.132602 |
| Popis: | In this study, Antimicrobial, Antifungal and Antibiofilm activity tests on 16 bacteria and 2 fungi of Salvia marashica Ilcim, Celep & Dogan and Salvia caespitosa Montbret & Aucher ex Benth species were performed by Agar Well Diffusion and Microdilution methods. Salvia species showed sensitivity with a zone diameter of 12–16 mm. Concentrations of 0.5 mg/ml to 16 mg/ml by the dilution method were used to determine the Minimum inhibited concentration (MIC) and Minimum bactericidal concentration (MBK). The MIC values of the plants are mostly 0.5 mg/ml - 4 mg/ml and MBC values are between 0.5 mg/ml - 8 mg/ml. Antifungal activity findings are remarkable on the species and it has been observed to have very high effects especially on Candida parapsilosis. When the antioxidant research findings are examined; It was observed that Salvia marashica and Salvia caespitosa plants have approximately 75% antioxidant activity at 1 mg/ml, and findings mostly directly proportional between concentrations and antioxidant activity capacity were recorded. MCF-7 and HUVEC cell lines were used to investigate anticancer activity properties. In line with the findings, while the IC50 value of Salvia marashica on the MCF-7 Cell line was 0.125 mg/ml, it was 1.65 mg/ml in the HUVEC cell line, while the IC50 value of Salvia caespitosa on the MCF-7 Cell line was 0.115 mg/ml in the HUVEC Cell line. It was found to be 9.87 mg/ml. It has been proven that both Salvia species have a cytotoxic effect on the MCF-7 Cell line. |
| Databáze: | OpenAIRE |
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