How various drugs affect anxiety-related behavior in male and female rats prenatally exposed to methamphetamine
| Autor: | Romana Šlamberová, I. Hrebíčková, E. Macúchová, Kateryna Nohejlová, Mária Ševčíková |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Drug Male medicine.medical_specialty Time Factors media_common.quotation_subject N-Methyl-3 4-methylenedioxyamphetamine Estrous Cycle Pharmacology Anxiety Methamphetamine 03 medical and health sciences 0302 clinical medicine Serotonin Agents Sex Factors Developmental Neuroscience Pregnancy Internal medicine medicine Animals Amphetamine Maze Learning media_common Estrous cycle Analgesics Analysis of Variance MDMA Rats 030104 developmental biology Endocrinology Mechanism of action Anxiogenic Prenatal Exposure Delayed Effects Morphine Exploratory Behavior Central Nervous System Stimulants Female medicine.symptom Psychology 030217 neurology & neurosurgery Developmental Biology medicine.drug |
| Zdroj: | International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 51 |
| ISSN: | 1873-474X |
| Popis: | Different forms of anxiety-related behavior have been reported after a single drug use of many abused substances, however, less is known about how males and females are affected differently from exposure to various drugs. Furthermore, chronic prenatal methamphetamine (MA) exposure was shown to predispose the animal to an increased sensitivity to drugs administrated in adulthood. Using the Elevated plus-maze test (EPM), the first aim of the present study was to examine how male and female rats are affected by acute drug treatment with subcutaneously (s.c.) administrated (a) MA (1mg/kg); (b) drugs with a similar mechanism of action to MA: amphetamine (AMP, 1mg/kg), cocaine (COC, 5mg/kg), 3,4-methylenedioxymethamphetamine (MDMA, 5mg/kg); and (c) drugs with different mechanisms of action: morphine (MOR, 5mg/kg), and Δ 9-tetrahydrocannabinol (THC, 2mg/kg). The second aim was to determine if prenatally MA-exposed (5mg/kg) animals show an increased sensitivity to adult drug treatment. The parameters analyzed were divided into two categories: anxiety-related behavior and anxiety-unrelated/exploratory behavior. Our results showed in female rats a decreased percentage of the time spent in the closed arms (CA) after MA, and an increased percentage of the time spent in the open arms (OA) after MA, AMP, and COC treatment, indicating an anxiolytic-like effect. In females, MDMA and THC treatment increased the percentage of the time spent in the CA. An increased percentage of the time spent in the CA was also seen after MOR treatment in females as well as in males, indicating an anxiogenic-like effect. As far as the interaction between prenatal MA exposure and adult drug treatment is concerned, there was no effect found. In conclusion, it seems that: (a) in some cases female rats are more vulnerable to acute drug treatment, in terms of either anxiogenic- or anxiolytic-like effects; (b) prenatal MA exposure does not sensitize animals to the anxiety-related effects of any of the drugs. |
| Databáze: | OpenAIRE |
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