Mezlocillin kinetics in hepatic insufficiency
| Autor: | Friedrich C. Luft, Michael E. Brier, C Martin Bunke, George R. Aronoff, Rebecca S. Sloan |
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| Rok vydání: | 1983 |
| Předmět: |
Adult
medicine.medical_specialty Kinetic analysis Penicillins Kidney Gastroenterology law.invention chemistry.chemical_compound Normal renal function Liver Cirrhosis Alcoholic law Internal medicine medicine Humans Infusions Parenteral Pharmacology (medical) In patient Pharmacology Creatinine Mezlocillin Clinical pharmacology Chemistry Liver Diseases Total body Elimination kinetics Middle Aged Kinetics Endocrinology medicine.drug |
| Zdroj: | Clinical Pharmacology and Therapeutics. 33:73-76 |
| ISSN: | 1532-6535 0009-9236 |
| Popis: | To establish elimination kinetics of mezlocillin in patients with hepatic insufficiency, we gave eight normal subjects and four patients with hepatic insufficiency and normal renal function a single 3-gm dose of mezlocillin by intravenous infusion. Subjects with hepatic insufficiency all had serum bilirubins levels of above 3 mg/dl, Prothrombin times more than 2 sec longer than control, and Creatinine clearances above 60 ml/min. Mezlocillin concentrations were determined by microbiologie assay. Kinetic analysis was by model-independent methods. Elimination half-life was 0.96 hr for subjects with normal liver function and 2.62 hr for patients with hepatic insufficiency. Mean total body clearance for normal subjects was 247 ml/min, while in patients with hepatic insufficiency it was 125.4 ml/min. We conclude that hepatic insufficiency prolongs mezlocillin elimination and suggest that therapeutic guidelines be set up. Clinical Pharmacology and Therapeutics (1983) 33, 73–76; doi:10.1038/clpt.1983.10 |
| Databáze: | OpenAIRE |
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