Remission vs low disease activity: function, quality of life and structural outcomes in the Early Rheumatoid Arthritis Study and Network
| Autor: | Paul Creamer, for Eras, Lewis Carpenter, Josh Dixey, Adam Young, David A. Walsh, Eran, Patrick D W Kiely, Sam Norton, Elena Nikiphorou |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
musculoskeletal diseases
rheumatoid arthritis Adult Male medicine.medical_specialty SF-36 Short form 36 Severity of Illness Index Disease activity Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine remission Rheumatology Quality of life Internal medicine Early ra medicine Humans Pharmacology (medical) In patient 030212 general & internal medicine skin and connective tissue diseases 030203 arthritis & rheumatology function business.industry Remission Induction Early rheumatoid arthritis Clinical Science Middle Aged medicine.disease humanities life quality low disease activity Rheumatoid arthritis Antirheumatic Agents Disease Progression Quality of Life Female business damage |
| Zdroj: | Rheumatology (Oxford, England) 2020, ' Remission vs low disease activity : function, quality of life and structural outcomes in the Early Rheumatoid Arthritis Study and Network ', Rheumatology, vol. 59, no. 6, pp. 1272-1280 . https://doi.org/10.1093/rheumatology/kez461 |
| ISSN: | 1462-0332 1462-0324 |
| DOI: | 10.1093/rheumatology/kez461 |
| Popis: | Objectives To examine associations between function, quality of life and structural outcomes in patients achieving remission vs low disease activity in early RA. Methods Demographic, clinical and radiographic variables were collected at baseline and then annually from the Early Rheumatoid Arthritis Study (ERAS) and Early Rheumatoid Arthritis Network (ERAN) inception cohorts in routine care from 1986 to 2012. Disease activity was categorized: mean DAS28 score between years 1 and 5: remission [mean remission DAS (mRDAS) Results Of 2701 patients, 562 (21%) were categorized mRDAS, 330 (12%) mLDAS, 279 (10%) sRDAS, 203 (7.5%) sLDAS and 93 (3%) sBR. Patients categorized as mRDAS had increasingly divergent improved HAQ, SF-36 PCS, MCS and total SvdH scores compared with mLDAS (P-values 0.001 to Conclusion These findings from routine care support ACR/EULAR guidelines that remission is a preferable goal over low disease activity in early RA. |
| Databáze: | OpenAIRE |
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