Pulmonary re-occurrence of post-transplant lymphoproliferative disease with hypogammaglobulinaemia
| Autor: | Eva Mildenberger, Karl Paul, Matthias T.F. Wolf, Rolf Keitzer, Thomas Lennert, Christina Zinn, Ioannis Anagnostopoulos, Hans T. Versmold |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Ganciclovir Epstein-Barr Virus Infections medicine.medical_specialty Lymphoma B-Cell Exacerbation Late onset Lung biopsy Gastroenterology Agammaglobulinemia Recurrence hemic and lymphatic diseases Internal medicine medicine Humans Child Lung business.industry Pneumonia medicine.disease Kidney Transplantation Lymphoproliferative Disorders Lymphoma Transplantation Cell Transformation Neoplastic surgical procedures operative medicine.anatomical_structure Pediatrics Perinatology and Child Health Immunology business medicine.drug |
| Zdroj: | European Journal of Pediatrics. 162:180-183 |
| ISSN: | 1432-1076 0340-6199 |
| DOI: | 10.1007/s00431-002-1120-8 |
| Popis: | We report the case of a 12-year-old boy, who developed Epstein-Barr virus (EBV) associated post-transplant lymphoproliferative disease (PTLD) 7 years after renal transplantation. He responded well to the reduced immunosuppressive therapy and treatment with ganciclovir. Two years later he developed severe pneumonia and hypogammaglobulinaemia related to EBV infection exacerbation. An X-ray film revealed persistent pneumonia in the right lung. Lung biopsy showed a large, diffuse EBV-associated B-cell lymphoma. This constellation suggested re-occurrence of the primary PTLD. Conclusion: We present a case of recurring Epstein-Barr virus-associated post-transplant lymphoproliferative disease with a remarkably late onset in addition to hypogammaglobulinaemia. |
| Databáze: | OpenAIRE |
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